Differential effects of LY294002 and wortmannin on neurons and vascular endothelial cells in the rat retina.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
Neuronal damage leads to capillary degeneration in an N-methyl-D-aspartate (NMDA)-induced retinal degeneration model; however, the mechanisms underlying this phenomenon are not fully understood. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway has been recognized as an intracellular pro-survival signaling system. Therefore, we used the PI3K inhibitors LY294002 and wortmannin to investigate the role of this pathway in neuronal and blood vessel injury in the rat retina treated with NMDA.
Authors and Affiliations
Kaori Ueda, Tsutomu Nakahara, Asami Mori, Kenji Sakamoto, Kunio Ishii
Keywords
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