Diffusion coefficient, porosity measurement, dynamic and equilibrium swelling studies of acrylic acid/polyvinyl alcohol (aa/pva) hydrogels
Journal Title: Pakistan Journal of Pharmaceutical Research - Year 2015, Vol 1, Issue 2
Abstract
Objective of the present work was to synthesize hydrogels of acrylic acid/polyvinyl alcohol (AA/PVA) by free radical polymerization by using glutaradehyde (GA) as crosslinkers. The hydrogels were evaluated for swelling, diffusion coefficient and network parameters like the average molecular weight between crosslinkâs, polymer volume fraction in swollen state, number of repeating units between crosslinks and crosslinking density by using Flory-Huggins theory. It was found that the degree of swelling of AA/PVA hydrogels increases greatly within the pH range 5-7. The gel fraction and porosity increased by increasing the concentration of AA or PVA. Increase in degree of crosslinking, decreased the porosity and inverse was observed in gel fraction. Selected samples were loaded with metoprolol tartrate. Drug release was studied in USP hydrochloric acid solution of pH 1.2 and phosphate buffer solutions of pH 5.5 and 7.5. Various kinetics models like zero order, first order, Higuchi and Peppas model were used for in vitro kinetic studies. The results showed that the drug release followed concentration dependent effect (First order kinetics) with non-Fickian diffusion. FTIR and SEM used to study the structure, crystallinity, and morphology of prepared and drug loaded hydrogels respectively.
Authors and Affiliations
Nazar Mohammad Ranjha
Keywords
Related Articles
- EP ID EP198739
- DOI 10.22200
- Views 142
- Downloads 0
Biofilm formation capability of bacteria, a threat to treat multi drug resistant diabetic foot infection isolates
Bacterial biofilms are complex structured communities surrounded in a matrix of extra-cellular polymeric substances growing on rough surfaces. It is involved in multiple functions like trapping of nutrients, adherence, s...
A Comparative analysis: In-vitro dissolution study of different commercially available brands of diclofenac sodium
The study was aimed to compare in-vitro release behavior of four commercially available brands of diclofenac sodium sustained release tablets. Most commonly used brands of tablets were taken randomly that contained same...
Development and application of spectrophotometric method for quantitative determination of Metronidazole in pure and tablet formulations
A rapid, simple and sensitive spectrophotometric method has been developed for the determination of metronidazole in pharmaceutical pure and dosage forms. The method depends on alkaline hydrolysis of metronidazole releas...
Thiolation of Polymers; A re-oriented approach towards targeted drug delivery.
Targeted drug delivery remains a challenge for the pharmaceutical scientists due to less solubility of API and less compatibility and contact time of excipients with mucous membrane. Modification in the composition of ex...
Advancement in Therapeutic Efforts and Tools for Prevention and Treatment of Insulin Dependent Diabetes Mellitis
Insulin Dependent Diabetes Mellitus (IDDM) is an autoimmune disease and is also called type 1diabetes. It occurs mostly due to CD8+ and CD4+ T lymphocytes which are actually the T-helper cells and very rarely by some vir...