Dipeptidyl Peptidase-4 Inhibitors and Cardiovascular Risk: Retrospective Study of 50 Type 2 Diabetic Patients with Chronic Heart Failure
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 20, Issue 11
Abstract
Objectives: The choice of antidiabetics in patients with heart failure is a major clinical concern. Some antidiabetic agents such as thiazolidinediones, more or less sulfonamides and insulin increase the risk of exacerbation of heart failure. There is controversy with regard to the cardiovascular risk associated with dipeptidyl peptidase-4 (DPP-4) inhibitors. The aim of this study was to evaluate the cardiovascular risk in patients with diabetes and heart failure treated with these medications. Patients and methods: A retrospective study was carried out from January 2014 to April 2015 at the Centre Hospitalier de Haguenau. The frequency of re-hospitalizations was studied (primary endpoint), as the duration of hospitalization and death in patients with type 2 diabetes and heart failure. Patients were divided into 2 groups, those treated with DPP-4 inhibitors (cases) and those not treated with DPP-4 inhibitors (controls). Results: Fifty regularly followed up type 2 diabetic patients with chronic heart failure were included in this study, of whom 32(64%) were men. Their mean age (SD) was 73.7 (± 7.6) years, ranging between 58 and 85 years. Twenty-four cases (48%) were treated with DPP-4 inhibitors. The rate of re-hospitalizations (primary endpoint) was 33.3% in the cases, and 26.9% in the controls (OR: 1.29, CI: 0.38 – 4.35, p=0.575). The duration of first hospitalization was 11.9 (±8.3) days in the cases, and 9.1 (±6.2) days in the controls (Risk ratio: 1.31, p=0.217). In-hospital mortality was not different between the 2 groups. Conclusion: Treatment with DPP-4 inhibitors was not associated with an increased risk of re-hospitalizations, duration of hospitalizations, and death in type 2 diabetic patients with heart failure.
Authors and Affiliations
Narcissse Ateba Assene, Patrick Hassler, Cecile Deharvengt, Ahmadou Musa Jingi, Monique Gladin, Emmanuel Andrès
Keywords
Related Articles
- EP ID EP311418
- DOI 10.9734/BJMMR/2017/22039
- Views 38
- Downloads 0
Low Concentration DMSO Stimulates Cell Growth and In vitro Transformation of Human Multiple Myeloma Cells
Aims: To evaluate the effect of Dimethyl sulfoxide (DMSO) on multiple myeloma (MM) cells. Study Design: Experimental study. Place and Duration of Study: Department of Pathology and Genomic Medicine, the Methodist Hospita...
Surgical Margins in Breast Cancer: Finally Defined?
It is proven that breast conservative surgery plus radiotherapy is safe and has equivalent results when compared to mastectomy. It is known that positive surgical margins increase the risk of local recurrence. The effect...
Factors Correlated with Low Birth Weight in Ghana
Aim: The aim of the paper was to assess factors associated with low birth weight in Ghana. Study Design: The study applied a cross-sectional population-based study design. Place and Duration of Study: The study used da...
Dentinal Tubules of Attrited, Abraded and Eroded Teeth- A Comparative Evaluation of Scanning Electron and Light Microscope
Aim: The aim was to study the ultrastructure of dentin exposed by attrition, abrasion and erosion separately and in combination and to visualize the lesions using scanning electron microscope and thereby establish a supe...
Serum Creatinine, Urea and Their CD4+ T-lymphocyte Count among HIV Positive Patients before and after Initiation of HAART at St. Paul’s General Specialized Hospital In Addis Ababa, Ethiopia
Objective: To describe the serum level of urea and creatinine, and as well as CD4+ T cell count of blood among HIV positive patients before and after initiation of HAART in St. Paulo’s general specialized hospital. Metho...