DIPYRIDAMOLE ATTENUATES THE GASTRIC INJURY IN ADULT AND AGED FEMALE RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 5
Abstract
Age is one of the important factors that affect the drug effects. Gastric ulcer is a common disease especially in elderly. Patients, especially elderly, who are treated with anti-platelet drugs may be exposed to a risk of gastric ulcers. Dipyridamole (DPY) is a platelet inhibitor that is primarily recognized as an antithrombotic agent. The aim of this study is to evaluate the age-dependent effects of DPY against cold restraint stress (CRS)-induced gastric ulcer in adult and aged rats. In addition, the possible mechanisms occupied in the effects were evaluated. DPY was suspended in 2% arabic gum solution and orally administered at a dose of 10 mg/kg once daily for 2 weeks and the last dose was administered 30 min before CRS. DPY exhibited gastroprotective effects in both adult and aged rats as evidenced by significant decreases in ulcer index (U.I). Both adult and aged DPY treated groups showed significant decrease in gastric mucosal malondialdehyde (MDA) concentration and myleoperoxidase (MPO) activity with concomitant increase in gastric mucosal content of reduced glutathione (GSH), nitric oxide (NO), prostaglandin E2 (PGE2) levels and gastric juice mucin concentration compared to CRS-induced gastric ulceration in adult and aged rats, respectively. This protective effect of DPY was confirmed by gastric histopathological examination. In conclusion, DPY protected both adult and aged rats’ gastric mucosa against CRS-induced gastric ulceration possibly through enhancement of gastric mucosal defense, anti-oxidant and anti-inflammatory activities. Accordingly it is concluded that DPY represents a suitable antiplatelet agent for patients who are at risk of gastric ulcers especially elderly patients.
Authors and Affiliations
Dr. S. Hassan
Keywords
Related Articles
- EP ID EP628312
- DOI -
- Views 181
- Downloads 0
EVALUATION OF TUBERCULOSIS DISEASE AWARENESS AND UNDERSTANDING AMONGST PHARMACY STUDENTS AT THE UNIVERSITY OF WOLVERHAMPTON
Introduction: Tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis is recognised as the leading cause of death due to infectious disease in the world. Pharmacies and pharmacy workers, together with GPs an...
ASSESSMENT OF THE LEVEL OF HEALTH CHECK AWARENESS AMONG STAFF OF DELTA STATE UNIVERSITY, ABRAKA, NIGERIA
Background: Early detection of diseases through health checks could help reduce complications and mortality from chronic diseases. Adopting preventive health behavior is essential for maintaining a productive workforce....
PREVALENCE OF UROPATHOGENIC ESCHERICHIA COLI & STAPHYLOCOCCUS AUREUS AMONG PATIENTS WITH CASES OF URINARY TRACT INFECTIONS ATTENDING BENUE STATE UNIVERSITY TEACHING HOSPITAL, MAKURDI
In the present study, we investigated the prevalence of few bacterial organisms associated with urinary tracts infection and their antimicrobial susceptibility patterns. Total of Ninety (90) midstream urine samples were...
COST-BENEFIT ANALYSIS OF PRENATAL DIAGNOSIS BY MOLECULAR KARYOTYPING VERSUS CONVENTIONAL KARYOTYPING FOR DETECTION OF ANEUPLOIDIES IN RAMATHIBODI HOSPITAL
Objective: To compare the benefit to cost ratio of prenatal diagnosis (PND) for aneuploidy between KaryoLite BACs-on BeadsTM (KL-BoBsTM) and conventional karyotyping techniques in health care purchaser's perspective. Stu...
PREVALENCE OF EXCESS WEIGHT IN STUDENTS FROM NORTHEASTERN BRAZIL
Objective: To assess the prevalence of the excess weight in adolescents from São Luís, Maranhão, Northeastern Brazil. Subjects/Methods: Cross-sectional study with a sample of 513 students aged 10-19 years from public sch...