Disorders of Insulin Synthesis and Secretion in Type 2 Diabetic Suffers after Disaster on ChNPS
Journal Title: Міжнародний ендокринологічний журнал - Year 2012, Vol 43, Issue 3
Abstract
There have been demonstrated the results of observation of 60 patients with type 2 diabetes mellitus divided into groups: the I one consisted of participants in the rectification of the consequences of the accident (PRCA) got radiation dose 0.25–0.9 Gy (38 persons), the II group included the inhabitants of radiation contaminated territory (accumulated doses during post-accident years on the average 8.3 cGy (15 persons)), the III group consisted of habitants of Kyiv (16 persons). The groups are comparable on age, disease duration, lipid metabolism disorders. The pancreatic insular apparatus functioning was estimated by determining glucose concentration, C-peptide, blood serum proinsulin under 2-hour mixed nutritive load (300 kсal, 80 % of carbohydrates, 20 % of fat and protein). PRCA were found to have increased blood serum concentration of proinsulin stimulated by postprandial glycemia while C-peptide level did not change. That indicates marked insulin resistance combined with insulin deficiency. The inhabitants of contaminated territory have decelerated reaction on postprandial glycemia associated with increased concentration of C-peptide and proinsulin in 120 minutes after nutritive load. In the persons not undergone radiation C-peptide and proinsulin concentration tended to increase, but PRCA had higher level of stimulated proinsulinemia in comparison with the habitants of contaminated territory and Kyiv.
Authors and Affiliations
A. N. Kovalenko, I. G. Chikalova, I. N. Muravyova
Keywords
Related Articles
- EP ID EP624202
- DOI -
- Views 70
- Downloads 0
Giant pituitary adenomas: prevalence, features of diagnosis clinical course
Based on the review of the literature, it is established that in the diagnostic complex with giant pituitary adenomas, in addition to clinical examination, it is necessary to use a full range of neuroimaging methods wit...
Indicators of transferrin and ferritin in overweigh and obesity children
Background. Today, obesity is seen as a chronic systemic inflammation of low activity. At present, the information about the biological and clinical significance of metal proteins in the inflammatory process is being acc...
Influence of diffuse nontoxic goiter on placental insufficiency, course of gestation and childbirth
Background. There are significant disorders in the functioning of the mother-placenta-fetus system in women with thyroid pathology, especially in chronic iodine deficiency. This leads to complications of pregnancy, child...
Correlation of the Structural Changes in the Thyroid Gland with Clinical and Laboratory Parameters in Patients with Diabetes Mellitus Type 2
The article presents the results of the study on the influence of clinical and laboratory parameters on the presence of structural changes in the thyroid gland (TG) of patients with diabetes mellitus (DM) type 2. Objecti...
Comparison of Infertility Causes Structure in Men and Women in Tashkent and Andijan Regions of Republic of Uzbekistan According to Screening Data
The structure of the causes of infertility has been studied in 100 couples (200 people) with infertility in Tashkent and Tashkent region (50 families in each). It is found that among surveyed women in the genesis of infe...