Dissolution Enhancement of BCS Class 4 Dssrugs Using Quality by Design Approach with Solid Dispersion Technique
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 1
Abstract
Solid dispersion is one of the vastly accepted and practically economical processes in bioavailability enhancement study. The present investigation deals mostly with increase in solubility and dissolution rate of BCS class 4 drugs for enhancement of oral bioavailability. For the same solid dispersion were prepared and analyzed for appropriate concentration of drug polymer ratio by phase solubility analysis. The solvent evaporation study widely accepted due to its efficient solid dispersion in lesser efforts. The study designs were prepared with specific concentration of drug and polymer ratio with the help of high throughput model i.e. Central Composite Design (by Design Expert trial copy) by specific design of experiment with full factorial design (DOE). The fixed variables were concentration of polymers and dependant variables were dissolution and permeability across bio-membrane in in-vitro model. The prepared dispersion investigated for dissolution and permeability improvement using USP Type II apparatus and modified everted gut sac model which leads to improvement of quality of whole formulation with Quality by design efficiently.
Authors and Affiliations
Pande S. V. , Biyani K. R.
Keywords
Related Articles
- EP ID EP406381
- DOI -
- Views 191
- Downloads 0
Source and Pharmacological Activities Of (-)-Anolobine and (+)- Anolobine
Many species of Annonaceae, Magnoliaceae, Lauraceae and Menispermaceae are used in African traditional medicine. Two molecules, (-)-anolobine and (+)-anolobine, previously isolated from eleven species of Annonaceae, two...
Immobilization and Death of Bacteria by Flora Seal® Microbial Sealant
A new advantage of cyanoacrylate surgicalmicrobial sealant, i.e. FloraSeal®, is that organisms dieshortly upon contact providing additional protection to the patient.
Insulin-like Growth Factor I (IGF-I) as a Predictive Factor of Retinopathy of Prematurity
Purpose: To establish the reliability of insulin-like growth factor 1 (IGF-1) as a prognostic factor for the onset and progression of retinopathy of prematurity (ROP). Patients and Methods: We examined 51 preterm infants...
Phytochemical Screening and Antimicrobial Effects of Leaf and Root Extracts of Crotalaria Brevidens on Candida Albicans, Staphylococcus Aureus and Escherichia Coli in Maseno (Kenya)
Crotalaria brevidens (slenderleaf) leaves and shoots are used as food and have medicinal properties when consumed by human beings. It also acts as an agent in promotion of suicidal germination of striga, a parasitic plan...
The Ability of Hydroalcoholic Extract from UrticaDioica to Suppress Di-(2-Ethylhexyl) Phthalate’s Deleterious Effect on Glycemic Response in Mice
Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer to impart flexibility during the production of polyvinyl chloride (PVC) to make medical devices, food containers, etc. Ingestion of DEHP can raise obesity and t...