The Ability of Hydroalcoholic Extract from UrticaDioica to Suppress Di-(2-Ethylhexyl) Phthalate’s Deleterious Effect on Glycemic Response in Mice
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 6
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer to impart flexibility during the production of polyvinyl chloride (PVC) to make medical devices, food containers, etc. Ingestion of DEHP can raise obesity and type 2 diabetes epidemics. Urticadioica (UD) has been known as a plant that decreases blood glucose. The objective of this study was to determine the effect of hydroalcoholic extract from urticadioica on glycemic response against DEHP. An interventional study with 15 adult male mice was designed. Mice were randomly assigned to 3 equal groups: control, DEHP (dose of 250 mg/kg/day), DEHP (dose of 250 mg/kg/day) plus extract of UD (dose of 100 mg/kg/day). They were treated for a period of 8 weeks. The formulated diet was common chow plus tallow (1:1). At the end, fasting blood samples were used to measure the variables. Serum glucose and insulin resistance (IR) levels of group 2 (DEHP 250 mg/kg) and group 3 (DEHP 250 mg/kg with extract of UD100 mg/kg/day) compared to the control group were increased significantly and also the insulin resistance (IR) level of group 3 compared to group 2 was decreased significantly (P < 0.05). The quantitative insulin sensitivity check index (QUICKI) levels of group 2 and group 3 compared to the control group were decreased significantly (P < 0.05). There were no significant changes in levels of serum insulin, glycated hemoglobin (HbA1c) of total blood and area under the curve in glucose tolerance test (AUC) (P > 0.05). In this study, it was shown that DEHP (250 mg/kg) impaired blood sugar control systems which can lead to prediabetes. We suggest that the extract of UD, by decreasing the IR level, may be useful to improve blood sugar control systems and may not be useful for reducing serum glucose level against DEHP.
Authors and Affiliations
BehzadNajmi Kargan, SanazAnvari Azar, Maryam Mahmoodi Momenabadi, Ranim Shartouni, Reza Fathi
Keywords
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