Dissolution Enhancement of Poorly Water Soluble Diacerein by Solid Dispersion Technique
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 11
Abstract
Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug, Diacerein by solid dispersion method using PVP K-30 and HPMC E4 as carriers. Four different formulations were prepared by solvent evaporation method with varying drug: carrier ratios viz.1:1, 1:2 1:3 and 1:4 and the corresponding physical mixtures were also prepared. The formulations were characterized for solubility parameters, drug release studies and drug-polymer interactions by using phase solubility studies, DSC, XRD analysis, FTIR spectrum. All the formulations showed marked improvement in the solubility behavior and improved drug release. Formulation containing drug: polymer ratio of 1:4 with PVP K-30 showed the best release 101.22% in 70 min as compared to the pure drug i.e. 63.48% in 120 min. The interaction studies showed no interaction between the drug and the carrier. It was concluded that PVP K-30 as a carrier can be well utilized to improve the solubility of poorly soluble drugs.
Authors and Affiliations
D. B. Deshmukh , P. D. Gaikwad , V. H. Bankar , S. P. Pawar
Keywords
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