PREPARATION AND EVALUATION OF TERNARY MIXING ITRACONAZOLE SOLID DISPERSIONS BY SPRAY DRYING METHOD
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 1
Abstract
The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drugby spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibility on thedegree of molecular dispersion of itraconazole solid dispersions are prepared by ternary mixing and polymer blendsare also evaluated for DSC, XRD and in vitro dissolution testing. Thermal analysis of DSC and XRD graphs wereanalysed to evaluate the status of glass transition state ternary solid dispersion phases. Among the formulations with15/85 (w/w) PEG/HPMC ratio was found better amorphous nature in relation with invitro release.
Authors and Affiliations
Rajarajan S, Beny Baby , Ramesh K, Dhananjay singh
Keywords
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