Phytochemical and Pharmacological Screening of the Plant Crateva Magna Against Alloxan Induced Diabetes in Rats.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
The plant Crateva magna belonging to family Capparaceae is used in anti spasmodic, hypotensive, anti inflammatory, hypoglycemic, anti protozoal, analgesic purposes. The present study was carried out to evaluate the effect of Crateva magna whole plant (ethanolic and aqueous extract p.o.) on alloxan induced diabetes in appropriate animal model. The study was carried out on alloxan induced diabetic model. The diabetes was induced by using Alloxan and Glibencamide (5 mg/kg) was used as standard drug. The aqueous extract of leaves of Crateva magna results maximum yield value than that of petroleum ether extract, chloroform extract and alcohol extract through successive maceration process. The aqueous extract of leaves of Crateva magna showed maximum control of blood sugar in hyperglycemic Wistar rats than other experimental extracts. The test extract also reduces the blood sugar level to a maximum extent in case of normal animals. So we finally came to the conclusion that the plant Crateva magna increases healing of diabetes and prevents the development of experimentally induced diabetes in Wistar rats.
Authors and Affiliations
Prabhat Das , Ranjan Sethi , S. Mekap , S. Pani
Keywords
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