Distortion Product Otoacoustic Emissions and High Frequency Audiometry for Early Detection of Cisplatin Induced Ototoxicity
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Ototoxicity is chemical injury to the labyrinth occurring as a side effect of pharmacotherapy.The most frequent pattern of hearing loss in cisplatin ototoxicity is a bilateral, symmetric, progressive, high frequency, sensoneural hearing loss, caused by loss of cochlear outerhair cells. The aim of this research was to study the pattern of changes in hearing status of patients undergoing cisplatin chemotherapy and to study the distortion product otoacoustic emissions and high frequency audiometry for early detection of ototoxicity in terms of hearing loss. Material and Methods: This study was conducted in the tertiary care teaching institute from January 2015 to June 2016. Total 63 patients were included in the study. After clinical examination all patients underwent Pure tone Audiometry (PTA), Distortion product otoacoustic emissions (DPOAEs) and baseline haematological investigations. A baseline PTA was done in all patients prior to the initiation of the cisplatin chemotherapy to detect any hearing loss before further evaluation of the patient. Results: In the present study30 (47.6%) patients were detected with significant ototoxic changes. Significant ototoxic changes were found in 27 (90.0%) patients by both the high frequency audiometry and Distortion product otoacoustic emissions at the same time. 3(10%) patients were picked up earliest by high frequency audiometry. Conclusion:We concluded that both the tests are equivalent and complementary in detection of cisplatin induced ototoxicity.
Authors and Affiliations
Manika Teotia, Sampan Singh Bist, Vinish Kumar Agarwal, Meenu Gupta
Keywords
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