Distribution of Methicillin-Resistant Staphylococcus aureus (MRSA) in Apparently Healthy Population and its Susceptibility to Saponins from Dialium guineense
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 18
Abstract
Aims: The ethanolic extracts of stem bark and fruit pulp as well as saponins from Dialium guineense were assayed for antibacterial activity against Gram positive and negative strains and clinical strains of methicilin resistant Staphylococcus aureus (MRSA) isolated from different locations on human body aged 20-30 years within the University of Nigeria community. Methodology: Agar diffusion technique was adopted. Results: The results showed that MRSA is predominant in apparently healthy population of the University community with 100% in males and 92.3% females showing positive case in nasal swab, 87.5% and 96.6 % positive from ear swabs of male and female volunteers respectively; and 77.7% positive from the high vaginal swabs of females. MRSA and other clinical isolates showed higher susceptibility to saponins compared to crude extracts; however, Bacillus cereus (NRRL 14724 and 14725) were not susceptible to the saponins from D. guineense. The MICs of the saponins were 31.25 mg/mL (B. subtilis ATCC 6051, P. aeruginosa, S. typhi, S. knitambo, P. mirabilis and S. aureus), 62.50 mg/mL (E. coli) and 125 mg/mL (P. aeruginosa ATCC 10145). Comparable MICs of higher values were obtained with the crude ethanolic extracts of stem bark and fruit pulp against MRSA and clinical isolates. Conclusion: The present findings revealed wide distribution of MRSA in an apparently healthy population in Nigeria and the susceptibility patterns showed the presence of a broad spectrum antibacterial agent in D. guineense.
Authors and Affiliations
W. O. Obonga, C. O. Nnadi, M. O. Agbo, F. C. Kenechukwu, U. Nwodo
Keywords
Related Articles
- EP ID EP344717
- DOI 10.9734/BJPR/2014/12943
- Views 94
- Downloads 0
Phytochemical and Biological Activities of the Wild Grape Fruit Extracts Using Different Solvents
Aims: To investigate the phytochemical, antioxidant and antibacterial activities of the solvent extracts of wild grape fruits in different colors. Study Design: The solvent extracts of wild grape (Ampelocissus martinii P...
Adsorption Kinetics and Equilibrium of Ciprofloxacin from Aqueous Solutions Using Corylus avellana (Hazelnut) Activated Carbon
The adsorption of Ciprofloxacin (CIP) from aqueous solutions by hazelnut shell activated carbon (HSAC) was studied in a batch adsorption system. Factors influencing CIP adsorption such as contact time (10-180 min), initi...
Assessment of Anti-atopic Dermatitis Activity of Oroxylum indicum Extract Incorporated Cream
Aims: The search for plant-based treatments against atopic dermatitis (AD), a relapsing dermatological condition with high prevalence in tropical regions, has always been attracting special attention. Among many folk rem...
Influence of Process Parameters on Compressibility, Solubility and Release Characteristics of Melt Sonocrystallized Fenofibrate
Aims: The aim of the present study was to investigate the suitability of the melt sonocrystallization (MSC) technique to modify the processability properties along with solubility and drug release of anti-hyperlipidemic...
Polypharmacy in the Elderly: The Need for Concern and Strategies for Its Control
In the last three decades, problems related to aging, multi-morbidity, and polypharmacy have become a prominent issue in global healthcare. In this study, Polypharmacy is defined as a concomitant use of five or more drug...