Influence of Process Parameters on Compressibility, Solubility and Release Characteristics of Melt Sonocrystallized Fenofibrate
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 12, Issue 1
Abstract
Aims: The aim of the present study was to investigate the suitability of the melt sonocrystallization (MSC) technique to modify the processability properties along with solubility and drug release of anti-hyperlipidemic drug fenofibrate (FNO) as a BCS Class II drug candidate. Study Design: By 32 factorial design. Place and Duration of Study: The study was performed in Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth-Vadagoan, Tal. Hatkanangale, Dist. Kolhapur, Maharashtra, India-416112 and the duration was two years. Methodology: Melt sonocrystallized fenofibrate agglomerates (MSC-FNO) were prepared by probe ultrasonicator at varying sonication time (1, 2 and 3 min) and level of amplitude (60, 70 and 80%) by 32 factorial design. Prepared MSC-FNO agglomerates were further evaluated for various parameters. Results: Stable MSC-FNO agglomerates were prepared successfully with adequate percentage yield and drug content having porous surface and different crystal habits such as needles, plates, and some hollow tubes. MSC-FNO has shown improved micrometric properties consequently compressibility and flowability than FNO. Also MSC-FNO has shown increase in solubility and drug release may be due to formation of porous agglomerates witnessed in Scanning Electron Microscopic photographs. These results were well supported by Differential Scanning Calorimetry and X-ray Powder Diffraction which has indicated decrease in crystallinity of drug. As sonication time and amplitude increased properties of MSC-FNO were proportionally improved. Study of Fourier Transform Infrared Spectroscopy revealed that no chemical transition of FNO has occurred during MSC. Conclusion: Thus MSC is a promising cost-effective technique that may give powder with improved required processability properties with better improvement in solubility and drug release, much needed for BCS class II drugs.
Authors and Affiliations
Sachinkumar Patil, Shitalkumar Patil, Geeta Kavathekar
Keywords
Related Articles
- EP ID EP342203
- DOI 10.9734/BJPR/2016/26590
- Views 73
- Downloads 0
Antioxidant Properties and HPLC Assay of Bioactive Polyphenols of the Ethanol Extract of Excoecaria agallocha Stem Bark Growing in Bangladesh
Aims: The ethanolic extract of Excoecaria agallocha stem bark was evaluated for antioxidant properties and quantification of bioactive polyphenols by HPLC-DAD. Methodology: ABTS assay, total antioxidant capacity, reducin...
Factors Predicting Erythropoietin Responsiveness among Maintenance Hemodialysis Patients: Prospective Longitudinal Study
Aim: To characterize the longitudinal hemoglobin (Hgb) variability in response to erythropoietin (Epo) and to identify the influence of clinical factors on Hgb level and Epo responsiveness in a sample of hemodialysis (HD...
Evaluation of the Anti-hyperlipidemic Activity of Ethanolic and Aqueous Extracts of Solanum melongena in Wistar Rats
Hyperlipidemia is characterized by hypercholesterolemia and/or hypertriglyceridemia and can lead to obesity, arteroscelerosis and hypertension among others. Although different types of oral hypolipidemic agents are avail...
Assessment of Antibiotic Self-medication Pattern among University Students in Eastern Democratic Republic of the Congo
Background: Self-medication with antibiotics has been reported among university students in many countries, but no study has been conducted on this issue in Democratic Republic of the Congo (DRC). Aim: This study aimed...
Hypoglycemic, Hypolipidemic and Antibacterial Activity of Ficus racemosa Fruit Extract
Background: Ficus racemosa, popularly known as the fig or cluster fig, is a traditional plant in the Moraceae family with various ethnomedical uses. However, the information of medicinal values of Bangladeshi grown Ficus...