DIURETIC ACTIVITY OF METHANOLIC AND ETHANOLIC EXTRACTS OF CENTELLA ASIATICA LEAVES IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 11
Abstract
Diuretics increase the rate of urine flow and are used to adjust the volume and composition of body fluids in a variety of clinical situations including hypertension, heart failure, renal failure, nephritic syndrome and cirrhosis. Traditionally, Centella asiatica has been used as antileprotic, anxiolytic, nootropic, antioxidant, antibacterial, antiviral and antiinflammatory agent. The present study was under taken to investigate the diuretic effect of methanolic and ethanolic extracts of Centella asiatica in wistar rats. The extract was given orally at a dose of 500mg/kg. Total urine volume and the concentration of sodium, potassium and chloride ions in the urine were taken into account during the experimental work. The extracts showed a significant diuretic effect with increase in electrolyte concentration in urine when compared with standard drug furosemide (20mg/kg p.o.). Relatively the ethanolic extract showed potent diuretic activity than the methanolic extract.
Authors and Affiliations
Roopesh Chitrala , Ruth Salomi, S. Nagarjuna, Padmanabha Reddy
SILICA SULFURIC ACID CATALYZED MICROWAVE-ASSISTED SYNTHESIS OF SUBSTITUTED BENZOXAZOLES AND THEIR ANTIMICROBIAL ACTIVITY
Substituted Benzoxazoles were synthesized by using microwave assisted treatment of orthoesters with o-aminophenols in presence of silica sulfuric acid to get the target compound. The structure of the synthesized compoun...
ANTIMUTAGENIC EFFECT OF TRIPHALA ON CHROMOSOMAL ABERRATIONS IN SWISS ALBINO MICE
Triphala is a herbal formula used in the ancient Science of Ayurveda. Triphala, a composite mixture of Terminalia bellerica, Terminalia chebula and Emblica officinalis, has been used in traditional system of medicine for...
COMPARATIVE STUDY ON THE SUBSTITUTES USED IN AYURVEDA WITH SPECIAL REFERENCE TO SUBSTITUTES FOR PUSHKARAMULA (INULA RACEMOSA HOOK.F.) VIZ., KUSHTA (SAUSSUREA LAPPA DECNE.) AND ERANDAMULA (RICINUS COMMUNIS L.): A CLINICAL STUDY
Ayurvedic literature introduced several substitutes for the herbs which are either not available or which are not accessible for various reasons. On review of more than 35 texts and their commentaries it is found that th...
STUDIES IN DISSOLUTION ENHANCEMENT OF ATENOLOL USING HP-βCD
Atenolol β1 cardio selective adrenoreceptor blocking agent, which is poorly soluble with only 40-50% bioavailability. In the present study attempt has been made to prepare and characterize inclusion complexes of Atenolol...
EFFECT OF SHORT TERM EXPOSURE OF BUTYLPARABEN ON UTERINE WEIGHT OF OVARIECTOMISED C3H ALBINO MICE
Butylparaben is a commonly used anti microbial preservative in cosmetics, pharmaceuticals and food. The high rate of human exposure of butylparaben has been of growing concern as it is found to mimic estrogen activity in...