Divergent Effects of Nigella Sativa Linn and Omebrazole on the Healing Of Gastric Ulcer in Adult Female Albino Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 4
Abstract
Gastric ulcer is one of the most common gastrointestinal tract diseases, and has affected on humans for centuries. Helicobacter pylori infection, use of drugs such as Nonsteroidal anti-inflammatory drugs (NSAIDs), and stress are some of the known factors that can cause gastric ulcers. NS (Nigella sativa) has been used in traditional medicine. It used for the treatment of a variety of diseases including gastrointestinal disorders. The aim of this study to evaluate the balanced between defensive and aggressive factors in the stomach and investigated the treated effects of NS ethanolic extract against Indomethacin induced gastric ulcer in rats. 48 Rats were divided at random into 6 groups 8 for each, 1st G negative control group treated with CMC 0.5 ml /kg BWt, 2nd NSG treated with NS 150mg/kg BWt, 3rd OG treated with Omebrazole 3 mg/ kg BWt, 4th IG Indomethacin group treated with 30mg / kg BWt, 5th INSG Indomethacin and NS, and 6th IOG Indomethacin and Omebrazole with the same dose. These studies revealed the successful effectiveness of the alcoholic extract of Nsativa seeds in doses of 150 mg/kg daily for two weeks in inducing significant (P< 0.05) treatment against gastric ulcer compared with IG. INSG and IOG showed a significant increase of RBCs x106 /mm3 , Neutrophils %, Prostaglandin E2 (PGE2 ng/l), NO3 µmol/ml and Reduced Glutathione GSH. and significant decrease of WBCs, HB, Lymphocytes %, PH, Total Acidity, Free Acidity , NO2 and MDA. Our results suggest that NS extract possesses significant antiulcerogenic actions in gastric ulcer induced by using indomethacin (as NSAIDs) that might be related to its anti-inflammatory and antioxidant activity.
Authors and Affiliations
1Mohamed N. Seddek, Salwa M. Thabet, Fawkyeia A. El-Hodairy,, Shaimaa A. Haredy
Keywords
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