DNA fragmentation in spermatozoa of men with infertility (literature review)
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 3
Abstract
In the literature review, data are analyzed on the violation of sperm DNA fragmentation and mechanisms of damage to DNA integrity in infertile men. The basic theories of molecular mechanisms of DNA damage and sperm chromatin abnormalities in male infertility are given. Adverse environmental conditions are generally recognized unfavorable factors, along with varicocele and pyospermia, congenital malformations and sexually transmitted infections, which affect the state of reproductive function in men. One of the mechanisms of damage to the sperm DNA integrity is high levels of reactive oxygen species. Data on the potential protective role of antioxidants in the treatment and prevention of DNA damage are presented. It was concluded that testing of sperm DNA damage and the selection of undamaged spermatozoa should be used as a part of diagnostic and therapeutic methods in couples suffering from infertility and repeated miscarriages.
Authors and Affiliations
V. Ye. Luchytsky, Ye. V. Luchytskyy, H. A. Zubkova
Concept of Diabetes Mellitus Type 2 Prevention: It’s Time to Act
.
Vitamin D status, calcium, magnesium and parathyroid hormone levels in patients with diabetes mellitus
Background. The purpose was to investigate the levels of 25(OH)D, parathyroid hormone, ionized calcium and magnesium in patients with type 1 and type 2 diabetes mellitus (DM) by comparison to the group of healthy person...
Indicators of transferrin and ferritin in overweigh and obesity children
Background. Today, obesity is seen as a chronic systemic inflammation of low activity. At present, the information about the biological and clinical significance of metal proteins in the inflammatory process is being acc...
Study of Features of Pregnancy in Women with Onset of Diabetes Type 1 in Prepubertal Period
We studied course of pregnancy in 22 patients with onset of diabetes type 1 in the prepubertal period. It is found that the need for insulin, depending on the duration of pregnancy, varied: decreased in the first trimest...
A Case of Pituitary Hypoplasia Combined with Achondroplasia in Six-Year-Old Boy
A case of achondroplasia combined with pituitary hypoplasia in 6-year-old boy is described. It is recommended to carry out magnetic resonance imaging of hypophysis in patients with achondroplasia to identify its possible...