DNA microarrays – future in oncology research and therapy
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2008, Vol 2, Issue 2
Abstract
DNA microarrays are a modern and powerful tool for investigating biological processes through the widespread analysis of genes from a particular cell, tissue, or organism. The completion of the human genome project and the development of microarray technologies have opened new opportunities for progress in cancer research. DNA microarrays analysis became a useful tool for the identification of molecular markers, as well as prognostic and diagnostic potential in different human cancers. The medical implications of the microarray technology are described in many publications, most of them as the result of studies on leukemia, lymphoma and breast cancer. There are also initial articles on the use of microarrays in veterinary oncology. Microarray analysis can be categorized into 3 groups of studies: 1) transcriptomic profi le of different tumour types to find characteristic genes for each tumour type, and the genes responsible for malignancy; 2) describing the disease and its clinical outcome; and 3) identifying therapeutic targets and new markers useful in cancer diagnosis and treatment.
Authors and Affiliations
Magdalena Król, Karol Pawłowski, Dorota Otrębska, Tomasz Motyl
Keywords
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