DNA TOPOISOMERASES: A REVIEW ON THEIR FUNCTIONALASPECTS IN CELL DIVISION
Journal Title: Era's Journal of Medical Research - Year 2018, Vol 5, Issue 2
Abstract
DNA is double helical macromolecule which carries all the genetic information and it is usually found enveloped inside a nucleus. The DNA helix relaxes and supercoils itself frequently in order to derive information from the genes during processes like transcription, condensation, replication and recombination, which require mutable or immutable alterations to cause the separation of the two DNA strands. Due to problems caused by the helical structure of DNA, these topoisomerase enzymes perform the required DNA uncoiling. Their role in cell cycle is also significant as their mutation leads to failure of anaphase separation (1, 2). In the present review, the important roles of DNA topoisomerases and their inevitable role in cell growth and cell cycle are discussed viz. how they function in cell proliferation and what are the results when different inhibitors are added to the cells, affecting cell cycle at various checkpoints .
Authors and Affiliations
Aditi Srivastava, Rumana Ahmad, A. N Srivastava
Keywords
Related Articles
- EP ID EP622240
- DOI 10.24041/ejmr2018.85
- Views 148
- Downloads 0
LEPTIN, THE MEDIATOR OF ENERGY RESERVE HAS ROLE IN FERTILITY: A REVIEW
Leptin, an adipocytokine was discovered in 1994 as putative hormone involved in appetite control acting at hypothalamic level. Since its discovery lot of work has been done over this novel molecule and in variety of phys...
STATUS OF TNF-α AND INSULIN IN OBESE AND DIABETIC OBESE SUBJECTS OF WESTERN LUCKNOW
Obesity has become a matter of quality to health care administrators. The busy lifestyle of people made them prefer fast food instead of taking healthy food. But the people are not aware that fast food habit converts to...
PAIN MANAGEMENT BY WHo STEP lADDER PATTERN PRoToCol IN CASES oF CERVICAl CANCER
To assess pain in cases of cancer cervix and to evaluate the response to pain management according to WHO step ladder pattern in cases of cancer cervix, total 209 carcinoma cervix diagnosed and admitted case were recruit...
CITRUS WASTE REUSE FOR HEALTH BENEFITS AND PHARMA-/NEUTRACEUTICAL APPLICATIONS
Citrus are the largest fruit crops grown across the globe. It is one of the most profitable crops in terms of economy as well as popular for nutritional benefits. The most interesting aspect about citrus is the availabil...
ROLE OF GST, TCF, ELMO1, TRPC1, IL-10 GENE POLYMORPHISM IN DIABETIC NEPHROPATHY
There are about 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. During the progression and development of DN, chron...