USE OF BIOLOGICAL PARAMETERS TO DE-ESCALATE CHEMORADIATION IN HPV ASSOCIATED SQUAMOUS CELL CARCINOMA OF DIFFERENT SUBSITES
Journal Title: Era's Journal of Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Human papillomavirus infection is now a well-established cause of many common cancers like cervical, other anogenital, and head and neck cancers. The mortality and morbidity rate associated with these cancers constitute a major burden especially for the underdeveloped and developing countries of the world, where they are more common. Traditionally, all these subsites are being treated with different chemoradiation protocols with variable results. Toxicities associated with the standard high dose chemoradiation protocols form a major obstacle in the completion of treatment for these patients and often affects the outcome negatively. Personal experience and published reports and reviews suggests that HPV associated squamous cell cancers are a distinct biological sub group of cancer which can be treated safely with reduced intensity of chemoradiation. The establishment of a similar de-intensified chemoradiation protocol for all HPV associated squamous cell carcinoma will certainly improve the quality of life of such patients.
Authors and Affiliations
Richa Chauhan
Keywords
Related Articles
- EP ID EP283031
- DOI 10.24041/ejmr2017.46
- Views 137
- Downloads 0
CANDIDA HAEMULONII : AN EMERGING PATHOGEN IN IMMUNOCOMPROMISED PATIENT SHOWING RESISTANCE TO AZOLES AND SUSCEPTIBILY TO ECHINOCANDINS
Emergence of a new species of non-albicans Candida species in Immunocompromised patient is a very alarming and life threatening trend. Accurate identification and prompt treatment in such patients is necessary to curtail...
CORRELATION BETWEEN TSH AND BODY MASS INDEX IN MALE AND FEMALE PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM
Hypothyroidism is a syndrome resulting from thyroid hormone deficiency or rarely inefficacy. It is a common endocrinological problem affecting especially women and the elderly. Thyroid hormones play an important role in...
THE STUDY OF NUTRIENT FORAMEN OF BONES OF ARM AND FOREARM IN ADULTS
The variation in presence of number of nutrient foramen is important in long bones as nutrient foramen gives passage for entrance of nutrient arteries in to the bone. The present study was conducted on total 114 dry huma...
KNOWLEDGE, ATTITUDE AND PRACTICES OF GENERAL PRACTITIONERS AND HOMEOPATHS REGARDING FOOD ALLERGY AND ANAPHYLAXIS IN INDIA- A COMPARITIVE STUDY
Food allergy (FA) is a growing health problem in India and worldwide with notable prevalence in infants when compared with children and adults. Multiple genetic and nutritional factors play an important role in etiology...
LANGUAGE IN MENTAL RETARDATION, SCHIZOPHRENIAAND HEARING- IMPAIRED (DEAFNESS)
This article depicts the situation and mode of language in different cases. Mental Retardation is considerably subaverage general intellectual functioning existing concomitantly with deficits in adaptive behaviour and ma...