USE OF BIOLOGICAL PARAMETERS TO DE-ESCALATE CHEMORADIATION IN HPV ASSOCIATED SQUAMOUS CELL CARCINOMA OF DIFFERENT SUBSITES
Journal Title: Era's Journal of Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Human papillomavirus infection is now a well-established cause of many common cancers like cervical, other anogenital, and head and neck cancers. The mortality and morbidity rate associated with these cancers constitute a major burden especially for the underdeveloped and developing countries of the world, where they are more common. Traditionally, all these subsites are being treated with different chemoradiation protocols with variable results. Toxicities associated with the standard high dose chemoradiation protocols form a major obstacle in the completion of treatment for these patients and often affects the outcome negatively. Personal experience and published reports and reviews suggests that HPV associated squamous cell cancers are a distinct biological sub group of cancer which can be treated safely with reduced intensity of chemoradiation. The establishment of a similar de-intensified chemoradiation protocol for all HPV associated squamous cell carcinoma will certainly improve the quality of life of such patients.
Authors and Affiliations
Richa Chauhan
Keywords
Related Articles
- EP ID EP283031
- DOI 10.24041/ejmr2017.46
- Views 181
- Downloads 0
SERoPREVAlENCE oF HEPATITIS B VIRUS IN PATIENTS ADMITTED To ERA’S lUCKNoW MEDICAl CollEGE AND HoSPITAl
Hepatitis-B Virus infections are a serious global and public health problem. To assess the magnitude and dynamics of disease transmission and for its prevention and control, the study of its seroprevalence is important....
DETECTION OF ACCESSORY RENALARTERIES IN NORTH INDIAN POPULATION: A CT STUDY
Presence of supernumerary renal artery (accessory renal artery) is the most common anatomical variation of renal arterial systemand is seen with varying frequencies among different ethnic and racial groups. Prior knowled...
CITRUS WASTE REUSE FOR HEALTH BENEFITS AND PHARMA-/NEUTRACEUTICAL APPLICATIONS
Citrus are the largest fruit crops grown across the globe. It is one of the most profitable crops in terms of economy as well as popular for nutritional benefits. The most interesting aspect about citrus is the availabil...
PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOGENOUS LEUKEMIA IN CHILDHOOD:A RARE CASE REPORT
CML is a clonal hematopoietic stem cell disorder. As per WHO classification, CML is included in Myeloproliferative disorder. Adult type - CML is rare in childhood constituting about 3% of childhood leukaemia. We have rep...
EFFECT OF ETHANOLIC SEED EXTRACT OF CITRUS LANATUS (WATERMELON) ON IMMUNOREACTIVITY OF HIPPOCAMPAL NEUROFILAMENT OF ADULT WISTAR RATS
Neurofilaments are major protein constituents of the brain, and play important roles in trafficking of molecules between neurons. An experimental study on thetotal protein content and immunoreactivity of neurofilament pr...