DOCKING STUDY OF ALLICIN WITH SULFONYLUREA RECEPTOR 1, COMPLEX 1 AND PPARγ RECEPTOR ON INSULIN RESISTANCE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 10
Abstract
Objective: Allicin is a potential type 2 antidiabetic. Sulfonylurea receptor 1 (SUR1), nikotinamida adina dinukleotida dehydrogenase (Complex 1) and peroxisome proliferator-activated receptors gamma (PPARγ) are known as important receptors responsible in insulin resistance This study aimed to determine the physicochemical properties, and the affinity of allicin on SUR1, Complex 1 and PPARγ receptors based on the binding energy and the type of interaction.Methods: The physicochemical properties of allicin were analyzed using ChemOffice, and the binding energy and type of interaction were analyzed using the docking method with Autodock Vina.Results: The results from the analysis showed allicin has log p (logarithmic partition) 1.35, massa relativity (mr) 162.26 g/mol, and the binding energy of allicin on SUR1, Complex 1 and PPARγ are respectively-4.0;-3.0; and-4.1 kcal/mol. The type of interaction between allicin and receptors is van der waals.Conclusion: Allicin has good permeability and has the potential to bind to SUR1, Complex 1 and PPARγ receptors contributing to the activity of allicin as antidiabetic.
Authors and Affiliations
Muhammad Andre Reynaldi, Hafrizal Riza, Sri Luliana
Keywords
Related Articles
- EP ID EP566141
- DOI 10.22159/ijpps.2018v10i10.28105
- Views 68
- Downloads 0
EVALUATION OF CARDIO PROTECTIVE ACTIVITY OF GALANGIN AGAINST DOXORUBICIN INDUCED CARDIOMYOPATHY
Objective: The present study was designed to investigate the cardioprotective potential of Galangin on Doxorubicin induced cardiotoxicity in rats.Methods: Albino rats used in this experiment were pretreated with vehicle,...
ANTIMICROBIAL ACTIVITY AND TLC PROFILING OF CLERODENDRUM PHLOMIDIS LINN. F LEAF EXTRACT AGAINST MULTI-DRUG RESISTANT CLINICAL PATHOGENS
Objective: The aim of the present study is to evaluate the antibacterial and antifungal activities of different solvent extracts of leaves of Clerodendrum phlomidis against multi-drug resistant clinical pathogens and to...
DEVELOPMENT AND VALIDATION OF A BIOANALYTICAL RP-HPLC METHOD FOR AZILSARTAN MEDOXOMIL WITH LIQUID-LIQUID EXTRACTION
Objective: There are many analytical methods available for estimation of Azilsartan medoxomil in biological samples and for pharmaceutical preparations. However, no specific RP-HPLC method with UV detection based on liqu...
FORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE
Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to dev...
PHARMACOKINETICS AND BIOAVAILABILITY OF TYLVALOSIN AFTER ORAL, INTRAMUSCULAR AND INTRAVENOUS ADMINISTRATION IN TURKEYS
Objective: Tylvalosin, is a new macrolide antibiotic, it is highly effective against a range of important diseases in many different veterinary species specially pigs and poultry. The pharmacokinetics and bioavailability...