Does Celiac Disease Effect Electrocardiographic Markers of Arrhythmic Events in Children?
Journal Title: The Journal of Pediatric Research - Year 2021, Vol 8, Issue 1
Abstract
Aim: Cardiac abnormalities associated with celiac disease (CD) have been reported. However, changes in electrocardiographic (ECG) parameters in children with CD have not been previously evaluated in the literature. In this study, we aimed to evaluate these parameters which may be determinative in the development of atrial and ventricular arrhythmia of children with CD. Materials and Methods: Patients diagnosed with CD in the gastroenterology clinic were included in the study. ECG measurements of QT, T peak to end (Tp-e) and P intervals were performed. The Tp-e/QT ratio was calculated from these measurements. Echocardiographic and ECG parameters of the patients and controls were compared. Those patients with elevated anti-tissue transglutaminase immunoglobulin A (IgAtTG) levels were considered positive serology. The patients were divided in three groups and compared with each other according to ECG parameters; namely newly diagnosed patients, patients with seropositive and patients with seronegative who had been on a gluten free diet for at least 6 months. Results: Fifty-two patients with CD and 59 healthy volunteers were included. P-wave dispersion, QTd, corrected QT dispersion (QTcd), Tp-e dispersion and TP-e/QT ratio were higher in those children with CD compared to the controls. We did not find any correlation between IgA-tTG levels and P-wave, QT and Tp-e dispersions. There was no difference between the three groups of CD patients for ECG and echocardiographic parameters. Conclusion: CD is associated with changes in some ECG parameters, which are considered as predictors of atrial and ventricular arrhythmias in special populations. For this reason, children with CD should be evaluated in terms of these parameters, and more electrophysiological studies are necessary to reveal the clinical and prognostic effects of these parameters for CD.
Authors and Affiliations
Tülay Demircan, Yeliz Çağan Appak, Maşallah Baran, Betül Aksoy, Barış Güven, Nazmi Narin, Cem Karadeniz
Keywords
Related Articles
- EP ID EP693586
- DOI 10.4274/jpr.galenos.2020.30316
- Views 127
- Downloads 0
A Decline in Aminotransferase Activity Due to Lifestyle Modification in Children with NAFLD
Aim: As obesity rates in children and adolescents increase, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease affecting this organ. This study aimed to evaluate the effectiveness of lifes...
A Case of Late-onset Hyperinsulinemic Hypoglycemia: HNF4A Mutation
Hyperinsulinemic hypoglycemia is a rare disease affecting infants and children. The frequency of HNF4A mutation is the third most common type following ABCC8 and KCNJ11 mutations. HNF4A inactivating mutations may cause h...
Evaluation of the Relationship between Mucosal Diseases and Faecal Calprotectin Levels in Children who Underwent Upper Gastrointestinal System Endoscopy
Aim: In this study, the correlation of faecal calprotectin (FC) levels with endoscopic and histopathological findings was evaluated in children who underwent upper gastrointestinal system (UGIS) endoscopy. Materials and...
Clinical Characteristics and Neurological Findings of Pediatric Patients with Acute Carbon Monoxide Intoxication
Aim: The aim of this study is to analyze children with acute carbon monoxide (CO) poisoning and to present two patients with rare neuroradiological findings. Materials and Methods: We identified and reviewed the medical...
Autoantibody Positivity in Children with Chronic Diarrhea
Aim: We aimed to determine the frequency of autoantibody antinuclear (ANA), peripheral anti-neutrophil cytoplasmic antibody (p-ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), anti-pancreatic exocrine gland antibody...