Does Glut-1 and Maspin Expression Have Prognostic Value in Uterine Cervical Carcinomas
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 10
Abstract
Aim: Cervical cancer is the the most common gynecologic malignancy worldwide with approximately 750,000 new cases annually. The aim of this study was to pose the histopathologic and clinical features of cervical carcinoma, as well as, the immunohistochemical expression of glucose transporter 1 (GLUT-1) and maspin, and their association with clinicopathological parameters in these cases and whether this relationship is effective with prognosis and survival. Methods: 114 patients were included in this study with the diagnosis of cervix carcinoma between 1992-2012. Tissue microaaray was performed and taken sections immunstained with GLUT-1 and maspin. The relationship is investigated between findings and prognostic factors, local recurrence, distant metastasis and survival. Results: Tumor type, lymph node invasion, and lymphovascular invasion (LVI) and clinic parameters like recurrence and metastasis have not show statistically significant difference with the presence of GLUT-1 and maspin immunreactivity. However, the relationship between maspin expression and stage shows statistically significant difference (p = 0.048) indicating that the higher expression of maspin is correlated with lower stages. Conclusion: In our study we observed that the presence of maspin expression and stage have shown statistically significant difference but we could not detect the same difference between GLUT-1 presence and stage. Also we did not find any correlation between GLUT-1 and maspin expression with the factors which are mentioned in the literature that affect prognosis and survival like stage, tumor type, lymph node status, LVI, involvement of parametrium.
Authors and Affiliations
Yasemen Adali
Keywords
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