Does hogg1 Ser 326 Cys Polymorphism Play Any Role in Gastric Carcinogenesis: A Case Control Study from Eastern India, Kolkata
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Aim: To investigate the association between Ser326Cys human oxoguanine glycosylase1 (hOGG1) polymorphism with gastric carcinogenesis and it’s relation with H.pylori in eastern Indian population. In the present prospective study, 168 patients with gastric cancer (GC), 170 subjects with dyspepsia were taken as disease control (DC) and 170 healthy controls (HC) were analyzed by PCR-RFLP method for genotyping of hOGG1 Ser326Cys to detect hOGG1 Ser326Cys (rs1052133) polymorphism. Endopscopic biopsy samples were subjected to Rapid urease test (RUT) and histopathological examination. Statistical analysis was conducted by two-sample t-test for continuous variables and χ 2 test for categorical variables. Logistic regression models were used to find the risk factors for gastric cancer. hOGG1 Ser326Cys genotypes were comparable among three groups. Neither heterozygous (Ser/Cys) nor mutant (Cys/Cys) allele was associated with gastric cancer upon comparison with the Ser/Ser genotype. P value for GC vs. DC was 0.148 and odds ratio (OR) for Ser/Cys was 1.39, (95% CI: 0.89-2.17) and p value for Cys/Cys was 0.436 and OR was 1.42 (95% CI: 0.58- 3.47). Conclusion: hOGG1 Ser326Cys polymorphism was not significantly associated with gastric cancer. No association was found in disease control group.
Authors and Affiliations
Kamalika Roy M. Sc, Prof. Tamal Kanti Ghosh MD, Sushil Kumar Phd, Prof UC Ghoshal MD
Keywords
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- EP ID EP593749
- DOI 10.9790/0853-1604037174.
- Views 86
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