Does Urinary Protein Excretion and Hypertension Significantly Correlate with Progression to End Stage Renal Failure?

Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 4

Abstract

Aims: To identify the prognostic factors possibly related to end-stage renal failure development. Materials & Methods: The prognostic factors affecting chronic renal failure progression were analysed in 456 patients aimed at verifying the role of protein restriction in slowing down or halting the progression of chronic renal failure. 311 patients completed the 24-month follow-up foreseen by the protocol and 69 reached an end-point. Using the Cox proportional hazard regression model, using a stepwise procedure in order to select only those factors, which are significantly associated with survival, made an inductive analysis on patient survival. For each individual risk factor, a univariate descriptive analysis of survival was performed using the Kaplan-Meier technique. Results: Underlying nephropathy, baseline plasma creatinine, proteinuria, and plasma calcium were all shown to be related to end-stage renal failure onset. Hypertensive patients (mean blood pressure > 107 mmHg) had a worst cumulative renal survival but the degree of proteinuria was even more important as a prognostic factor of renal death than hypertension. The cumulative renal survival of patients whose proteinuria decreased during the trial follow-up was better than those of patients without changes. However, the interaction between baseline lying mean blood pressure and proteinuria was not significant. Conclusions: Only primary renal disease and proteinuria were related to renal survival, being baseline plasma creatinine confounding factor. By blocking the possible causal role of proteinuria and hypertension, end-stage renal failure could be prevented in a significant percentage of patients.

Authors and Affiliations

Vikash Khandelia, Nilesh Jain, Ankur Jhanwar, Pavan Kumar Pyarsabadi, Saurabh Chittora, Umashankar Nama

Keywords

Related Articles

Anaesthetic Management of a Case of Hemophilia: A Case Report and Literature Review

Hemophilia A also known as classic hemophilia is a congenital hereditary bleeding disorder. It can present with variable symptoms along a spectrum between spontaneous bleeding and persistent bleeding after minor trauma o...

Quality of Life and Wellbeing of Patients with Celiac Disease in Aseer Region of Saudi Arabia

Background: It is known that people who suffer from celiac can't live natural life, they always have dissatisfaction feeling since most of time they can't enjoy with anything they have so, the aim of the study is to what...

Serum Homocysteine Levels in Non-Alcoholic Fatty Liver Disease Patients At Tertiary Care Hospital at Uttarakhand

Background: Non-alcoholic fatty liver disease (NAFLD) is a common disorder which causes serum liver enzyme elevation. Elevated homocysteine levels were demonstrated in fatty liver disease and chronic liver failure. Howev...

Assessment of Correlation of Bone Mineral Density and Vitamin D Status In Patients with Osteoarthritis of the Knee: A Clinical Study

Background: Vitamin D deficiency can be an important risk factor for osteoporosis. On the other hand, an adequate vitamin D level has been shown to prevent osteoporotic fractures. Bone mineral density (BMD), which measur...

Incidence and Risk Factors for Retinopathy of Prematurity in Premature Born Children in Tabuk City

Introduction: Retinopathy of prematurity (ROP) is a disease of the eye that considers as one of a complication of preterm birth which characterized by abnormal growth of retina blood vessels at a junction of the vascular...

Download PDF file
  • EP ID EP546543
  • DOI 10.21276/ijmrp.2017.3.4.002
  • Views 102
  • Downloads 0

How To Cite

Vikash Khandelia, Nilesh Jain, Ankur Jhanwar, Pavan Kumar Pyarsabadi, Saurabh Chittora, Umashankar Nama (2017). Does Urinary Protein Excretion and Hypertension Significantly Correlate with Progression to End Stage Renal Failure?. International Journal of Medical Research Professionals, 3(4), 7-111. https://europub.co.uk/articles/-A-546543