A Comparative Study Between Prostaglandin F2α and Methylergometrine In the Active Management of Third Stage of Labor
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4
Abstract
Introduction: The most serious complication in obstetric practice is post-partum haemorrhage (PPH) The greatest number of maternal deaths from haemorrhage is due to PPH, which is almost entirely a preventable condition Postpartum haemorrhage (PPH) is one of the most common causes of maternal mortality. The study aimed at comparing the efficacy safety and tolerability of intramuscular Prostaglandin 2α versus intravenous Methyl Ergometrine in the active management of the third stage of labor and to compare the efficacy of the above two drugs. Material and Methods: A total of 100 women in labor were included in the study. Women were randomized to one of the two groups. Active management of the 3rd stage of labor was done in Group II with intravenous methylergometrine (0.2microgram) and in Group I with intramuscular Prostaglandin 2α (125 micrograms). Results: There was no significant difference if blood loss in 1st hour of third stage of labor for both the groups. Nevertheless, blood loss was significantly lesser at 4th hour and total 3rd stage of labor in group II prostaglandin F2 α group compare to methylergometrine group. None of the woman developed PPH in either group. Conclusion: Results of the present study suggest that both methylergonovine and 15-methyl PGF2α have great viability when utilized as a prophylactic measure for PPH. 15-methyl PGF2α was observed to be more useful in protecting the blood loss during first four hours of third stage labor when contrasted with methylergonovine in the examination. However, the unfavourable medication responses related with 15-methyl PGF2α are more when contrasted with that of methylergonovine. Likewise, the cost required with 15-methyl PGF2α is considerably higher. In this manner 15-methyl PGF2α can be suggested in situations where methylergonovine is contraindicated, and in cases refractory to other uterotonic operators. Findings of the present study suggest that 15-methyl PGF2α doesn't have all the capabilities to replace the methylergonovine which the medicine of first choice in the management of third stage of labor.
Authors and Affiliations
Poonam Singh
Keywords
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- EP ID EP535474
- DOI 10.21276/ijmrp.2018.4.4.057
- Views 101
- Downloads 0
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