Donepezil Related Neuroleptic Malignant Syndrome
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
The purpose of the paper is to report a case of development of neuroleptic malignant syndrome (NMS), in a 55year old Assamese male patient receiving low dose oral haloperidol 2.5mg/day and Trihexyphenidyl 4mg /day in divided doses which he was tolerating well until after the addition of oral Donepezil 5mg /day following which he developed NMS. Antipsychotics and cholinesterase inhibitor have direct propensity to induce neuroleptic malignant syndrome but it is a very rare event, when given in together they undergo complex interaction to induce NMS and therefore should be chosen very carefully.
Authors and Affiliations
Dr Angshuman Kalita, Dr Ambu Pandey, DrKunal Deb, Dr. Soumik Sengupta
Keywords
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- EP ID EP557888
- DOI 10.9790/0853-1803140103.
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