DOPAMINE IN SCHIZOPHRENIA IT’S TREATMENT WITH NEWER ATYPICAL ANTIPSYCHOTICS: AN OVERVIEW
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels and behaves. People with schizophrenia may seem like they have lost touch with reality. Although schizophrenia is not as common as other mental disorders, the symptoms can be very disabling. Dopamine is the main catecholamine in the CNS; and is involved in a variety of physiological functions, including sexual behavior, cognition, motor coordination, cardiovascular control, reward and hormonal regulation. Abnormalities in dopaminergic neurotransmission have been implicated in Parkinson‘s disease, schizophrenia, attention-deficit disorder and depression. Modern treatment for schizophrenia relies primarily on somatic drug therapy Psychotic illness includes various disorders but the term antipsychotic drugs also known as neuroleptics drugs, antischezophrenic drugs. The development of atypical antipsychotics is an important milestone in the history of psychiatry, because it brought effective treatment option with a reduced risk for adverse events. Four dopamine pathways in the brain play a role in the pathophysiology of schizophrenia as well as the therapeutic effects and side effects of antipsychotic agents. Activity in each of them has a unique set of physical, cognitive and psychological effects.
Authors and Affiliations
Amol S. Jagdale
Keywords
Related Articles
- EP ID EP674627
- DOI -
- Views 190
- Downloads 0
ANALYSIS OF THE MONOSODIUM GLUTAMATE ON NEUROTRANSMITTERS USING QUANTUM METHOD
Monosodium glutamate (GMS) is a sodium salt used as enhancer additive flavor. This GMS is one of the chemicals responsible for maintaining the flavor of long-lasting food. According to studies carried out, consumption of...
THE IMPACT OF STRESS ON IMMUNITY, MECHANISM AND PATHWAYS INVOLVED
This is established fact that stress is harmful for human body. There is a need to identify the adaptive and curative measure to manage physiological stress reaction at the time of fight and flight. Usually treatment of...
EFFECT OF POMEGRANATE (PUNICAGRANATUM L.) (ARILS, PEELS AND SEEDS) EXTRACTS ON FATTY LIVER IN RATS
Objectives: This study aimed to investigate the ameliorative effect of pomegranate extracts (arils, peels, and seeds) on nonalcoholic fatty liver disease in rats. Methods: The nonalcoholic fatty liver disease was induced...
X GENE VARIABILITY AND GENOTYPING OF HEPATITIS B VIRUS (HBV) IN SUDANESE PATIENTS WITH LIVER DISEASES, KHARTOUM, SUDAN
Background: HBx gene mutations may have a role in the progression of liver disease from chronic infection to liver cirrhosis and/or hepatocellular carcinoma. These mutations affect the biological functions of HBx protein...
COMPARISON OF INTRAOPERATIVE BLOOD LOSS DURING SPINAL SURGERY USING EITHER ISOFLURANE, SEVOFLURANE AND COMBINATION PROPOFOL + REMIFENTANIL AS AN ADJUVANT TO GENERAL ANESTHESIA
Background: Decrease of bleeding is of significant importance in keeping the patient’s hemodynamic stabilized, and also in creating a blood-free field with a good vision for the surgeon. The purpose of this study was to...