Doppler Indices of Uterine, Umbilical and Fetal Middle Cerebral Arteries Before and After Sildenafil Citrate and Transdermal Nitroglycerin in Cases Suffering from Intrauterine Growth Restriction
Journal Title: Gynecology and Obstetrics Research – Open Journal - Year 2018, Vol 5, Issue 1
Abstract
Introduction Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality. Its diagnosis and treatment constitute one of the most important challenges of present day obstetrics. A drug that could improve maternal and fetal hemodynamics in the setting of early intrauterine growth restriction has potential benefit for at least palliation of this ominous condition. In most instances the etiology of IUGR is unknown. The absence of a uniform etiology may help one understand the existence of the large number of treatments suggested for correcting the problem Patients and methods The objective of this study was to compare the effect of transdermal nitroglycerin and oral Sildenafil citrate on Doppler indices of uterine, umbilical and fetal middle cerebral arteries, and changes in fetal weigh, abdominal circumference and amniotic fluid volume in fifty pregnant women who attended inpatient and outpatient clinics in the department of Obstetrics & Gynecology in Tanta University Hospitals, and suffering from asymmetrical intrauterine growth restriction. Results of the study proved a clear significance of the growing role of transdermal nitroglycerin and Sildenafil citrate for augmenting, feto-placental blood flow in the setting of placental vascular insufficiency and IUGR, as a significant reduction in umbilical artery RI, uterine artery RI in the two groups, also abdominal circumference, AFI and estimated fetal weight were significantly increased after 21 days from treatment. That gives a promising treatment for IUGR patients.
Authors and Affiliations
Ahmed Mohammed El-Bheirey
Keywords
Related Articles
- EP ID EP553867
- DOI 10.17140/GOROJ-5-146
- Views 152
- Downloads 0
A Novel Contributor to Endometrial Receptivity: Endometrial Microbiota
In the recent years, our knowledge about human reproductive system has increased with the development of assisted reproductive technologies; however, embryo implantation rate is still around 25-30%.1 Embryo implantation...
Different Uses of Chitosan for Treating Serious Obstetric Hemorrhages
Postpartum hemorrhage is a major cause of maternal death worldwide. Many therapeutic strategies have been developed to reduce maternal morbidity and mortality like oxytocin, prostaglandin, and uterine balloons. A new mem...
Changing the Algorithm in the Evaluation of Pelvic Anatomy in the Infertile Patient: Is Hysterosalpingo Contrast Sonography With Saline-Air Device the Appropriate Test for Everyone?
The evaluation of the fallopian tubes is an essential part of the infertility workup, with abnormalities related to the fallopian tubes accounting for up to 40% of female subfertility.1 Laparoscopy is still considered th...
Heterotopic Pregnancy: A Case Report of Retrospective Diagnosis Following Surgical Treatment
Introduction: Heterotopic pregnancy is a rare occurrence. Very few clinicians may come across heterotopic gestations during their careers. It is a difficult condition to diagnose. It can lead to maternal mortality. Case...
Interactions of Immunomodulatory HLA-G with Immune Cells during Pregnancy and Endometriosis
The Major Histocompatibility Complex (MHC), the genetic region that encodes the proteins responsible for tissue graft rejection,1 encodes MHC Class I (MHC-I) and MHC Class II (MHC-II) glycoproteins. There are two subclas...