DOSAGE RESPONSE OF PIMPINELLA TIRUPATIENSIS TUBEROUS ROOT EXTRACT ON HYPERGLYCEMIC CONDITION IN STZ- INDUCED DIABETIC RATS WITH REFERENCES TO SHORT AND LONG TERM TREATMENT

Abstract

Objectives: To evaluate the antidiabetic effect of three extractions [n-Hexane (n-HE), ethyl alcohol (EAE) and aqueous extract (AE)] of Pimpinella tirupatiensis (Pt) tuberous root on the fasting blood glucose (FBG) level of rats during streptozotocin (STZ) induced diabetes.Methods: Experimental diabetes was induced by intra peritoneal injection of STZ (40 mg/kg b.w.). FBG level was determined at 0 hour (before extract [DS1] administration), 1st, 3rd 5th and 7th hour (after extract administration) by using electronic glucometer (accucheck).Results: We observed, AE showed a maximum efficacy with a dosage of 750 mg/ kg b.w. at 5th hour which is about 49% reduction in FBG level over zero time values. Hence, we have selected 750 mg dose of AE of Pt to investigate the long term effect on down regulation of blood glucose level. Oral administration of AE (750 mg/kg b.w./day) for 30 days showed a significant antihyperglycemic effect in diabetic rats. However, no significant changes were noticed in blood glucose level in normal rats treated with AE alone. It seems AE considerably reduced the blood glucose concentration in a similar manner to that of reference drug glibenclamide (20 mg/kg b.w.) in diabetic rats.Conclusion: These results suggest that Pimpinella tirupatiensis aqueous extract is beneficial in the control of diabetes by reduction of blood glucose levels.

Authors and Affiliations

Rajeswara Reddy, Thopireddy Lavanya, Kesireddy Sathyavelu Reddy

Keywords

Related Articles

PREPARATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF DROTAVERINE HYDROCHLORIDE USING SUBLIMATION TECHNIQUE

Objective: To formulate orally disintegrating taste masked tablets of drotaverine hydrochloride (HCl) by sublimation technique.Methods: Initially superdisintegrant was selected and its concentration was optimized by pre-...

PHARMACEUTICAL COCRYSTAL OF PRULIFLOXACIN WITH NICOTINAMIDE

Objective: Cocrystals have been increasingly recognized as an attractive alternative for solid forms of drug products. In this work nicotinamide (NCT) was employed to form the cocrystal with the active pharmaceutical ing...

EVALUATION OF ANTIBACTERIAL POTENTIAL OF SILVER NANOPARTICLES (SNPs) PRODUCED USING RHIZOME EXTRACT OF HEDYCHIUM CORONARIUM J. KOENIG

Objective: The bio-reduction of silver ions in solution into silver nanoparticles by rhizome extract of Hedychium coronarium as capping, reducing and stabilizing agent. Further, to evaluate the antibacterial activity of...

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF FORMULATION CONTAINING CAMPHOR, MENTHOL AND THYMOL

Objective: To determine analgesic and anti-inflammatory activity of a oily formulation containing camphor, menthol and thymol as ingredients in wistar albino mice and rats.Methods: Acute toxicity studies were done as per...

VITRO ANTIOXIDANT PROPERTIES AND WOUND HEALING ACTIVITY OF HYDROETHANOLIC TURMERIC RHIZOME EXTRACT (ZINGIBERACEAE)

Objective: In the present study, we evaluated the ethno pharmacological effect of the different doses of Turmeric rhizome hydroethanolic extract ointment (TRO), using in vitro antioxidant activity and in vivo excision, i...

Download PDF file
  • EP ID EP579101
  • DOI -
  • Views 67
  • Downloads 0

How To Cite

Rajeswara Reddy, Thopireddy Lavanya, Kesireddy Sathyavelu Reddy (2015). DOSAGE RESPONSE OF PIMPINELLA TIRUPATIENSIS TUBEROUS ROOT EXTRACT ON HYPERGLYCEMIC CONDITION IN STZ- INDUCED DIABETIC RATS WITH REFERENCES TO SHORT AND LONG TERM TREATMENT. International Journal of Pharmacy and Pharmaceutical Sciences, 7(2), 389-392. https://europub.co.uk/articles/-A-579101