Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
Journal Title: Journal of Interdisciplinary Histopathology - Year 2013, Vol 1, Issue 2
Abstract
B-cell lymphomas with concurrent MYC with BCL2 and/or BCL6 rearrangements, also known as “double hit” lymphomas (DHL), are rare neoplasms characterized by highly aggressive clinical behavior, complex karyotypes, and a spectrum of pathological features overlapping with Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Primary renal lymphoma (PRL) by definition is a renal lymphoma without evidence of systemic involvement. PRL is extremely rare with less than 100 cases of both Hodgkin disease and non-Hodgkin lymphoma reported in literature. Double hit lymphomas have extremely poor prognosis, and high resistance to intensive chemotherapy, including high-dose chemotherapy. We describe a very rare case of DHL arising in kidney as PRL in whom concurrent MYC and IGH-BCL2 rearrangements were detected.
Authors and Affiliations
Vikas Mehta, Chandy Ellimottil, Jodi Speiser, Milind Velankar, Güliz Barkan
Keywords
Related Articles
- EP ID EP135611
- DOI 10.5455/jihp.20130121075815
- Views 77
- Downloads 0
Cytomegalovirus endometritis in a non-immunosuppressed patient presenting as recurrent pyometra: A case report
Cytomegalovirus infection of the female genital tract is a rare entity. We present a case of 70-year-old woman who came with recurrent pyometra but was otherwise in good health. Hysterectomy was done, and the endometrium...
Protective eff ect of rosemary (Rosmarinus offi cinalis) extract on naphthalene induced nephrotoxicity in adult male albino rat
Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is use...
Tubo-ovarian actinomycosis mimicking ovarian malignancy: Case report
Actinomycosis is a chronic suppurative granulomatous infection caused by Actinomyces israelii, an anaerobic Gram-positive microorganism. Pelvic actinomycosis is rare and constitutes 3% of all human actinomycosis infectio...
Towards A Closer Way of Thinking among Different Disciplines
Eff ects of menopause and diabetes on the rat thyroid gland: A histopathological and stereological examining
Objective: Menopause is described as the arrest of the menstruation cycle and ending of reproductive potential. Diabetes mellitus (DM) occurs with Type 1 diabetes that is originated from the absence of insulin and Type 2...