Drug correction of endothelial dysfunction in children with chronic pyelonephritis
Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 7
Abstract
Background. Timely and sufficient drug correction of endothelial dysfunction in children with chronic pyelonephritis determines the effectiveness of preventing its progression, improves cardiovascular and renal prognosis. The purpose of the study was to examine the effectiveness of various regimens of drug correction for endothelial dysfunction in children with chronic pyelonephritis. Materials and methods. Thirty seven children aged 11–17 years with non-acute chronic pyelonephritis were examined. Thus, the first group of 17 patients received baseline therapy of chronic pyelonephritis, including angiotensin-converting enzyme (ACE) inhibitor enalapril; the second group of 20 patients in addition to standard therapy with ACE inhibitor received the intravenous infusion of L-arginine and then took its oral solution. Results. Patients in the first group had a tendency to increase in the diameter of the brachial artery at rest (2.4 ± 0.1 mm), in the phase of maximal vasodilation (2.9 ± 0.1 mm), without a significant difference from the state before the treatment. An increment of the brachial artery diameter after the treatment had significantly increased in comparison with the level before the treatment (12.00 ± 0.39 mm). Moreover, the reduction of linear blood flow velocity at rest was not statistically significant (146.90 ± 1.13 cm/s). In the second group, there was a significant increase in the brachial artery diameter at rest (2.80 ± 0.13 mm) and in the phase of maximal vasodilation (3.40 ± 0.14 mm) as compared to the baseline. Meanwhile, an increase in the brachial artery diameter after treatment was not significantly different from the physiological norm (17.20 ± 0.41 mm). The linear blood flow velocity at rest was close to the value in the control group, with no significant difference (141.20 ± 1.16 cm/s). In general, the manifestations of endothelial dysfunction decreased by 26.9 and 47.8 % in the first and second groups, respectively. Conclusions. In patients with chronic pyelonephritis without manifestations of chronic renal failure, monotherapy with ACE inhibitor enalapril is effective. In patients with manifestations of chronic renal failure degree I–II, it is advisable to use combined therapy with L-arginine.
Authors and Affiliations
L. I. Vakulenko
Keywords
Related Articles
- EP ID EP423720
- DOI 10.22141/2224-0551.13.7.2018.148919
- Views 113
- Downloads 0
Annular Pancreas Associated with TORCH-infection
The article presents follow-up in a newborn child with a congenital malformation of the gastrointestinal tract (annular pancreas), III degree prematurity against the background of persistent cytomegalovirus and toxoplasm...
Experience of Application of Domperidone in Suspension in Infants with Regurgitation Syndrome
The article deals with the experience of using domperidone (Domrid) in suspension in infants with regurgitation syndrome. A research group consisted of 42 patients aged ge from 1 to 12 months with regurgitation with vari...
Evaluating the efficacy of probiotics in atopic dermatitis on the background of food allergy in children
Background. According to the European Academy of Allergy and Clinical Immunology, about 17.3 % of European population has food allergies throughout life. At the same time, an increased concentration of specific immunoglo...
Experience of Berodual Use in Infants with Bronchial Obstruction Syndrome
The paper shows the effectiveness of Berodual use as inhalations via nebulizer in infants with bronchoobstructive syndrome as a bronchodilator of emergency care.
To the Question on Urine Diversion in Congenital Hydronephrosis in Children
Introduction. Hydronephrosis in children is an obstruction of pyeloureteral segment, which is usually diagnosed antenatal by ultrasound screening in 1.5 % of pregnancies. Pathophysiology is still unknown. The most common...