Drug-Related Problems in Hypertensive Patients with Multiple Comorbidities
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 3
Abstract
Hypertensive patients with multiple comorbidities often received multiple medications to achieve target blood pressure and to treat other comorbidities which can lead to the occurrence of drug-related problems (DRP). The objectives of this study were to identify the DRPs and the most common drugs associated with DRPs in this population. The study was conducted prospectively involving hypertensive patients with multiple comorbidities at a tertiary care centre. Data were obtained from bed head tickets and from the interview with eligible patients. The assessment of DRPs was based on Pharmaceutical Care Network Europe Foundation (PCNE) Classification of DRP tools version 5.01. From the total of 80 patients, 88.8% of the patients had at least one DRP. A total number of 172 DRPs were identified with an average of 2.15 ± 1.5 DRPs per patient. The most frequent category of DRP was interactions (33.7%), followed by adverse reactions (23.9%), drug choice problems (14.5%), dosing problems (13.4%), others (8.1%) and drug use problems (6.4%). Antihypertensive agents were the most common drugs associated with DRPs in this population. Significant associations were found between elderly and the occurrence of adverse reactions, and between renal impairment with the occurrence of drug choice problems and over dosage problems. This study demonstrates that DRPs were frequently observed in hypertensive patients with multiple comorbidities. Thus interventions to resolve these problems are important to ensure the effectiveness and safety of the prescribed medications.
Authors and Affiliations
Redzuan AM*, Ramli AR and Pheng MTH
Keywords
Related Articles
- EP ID EP745761
- DOI 10.23880/oajpr-16000113
- Views 1
- Downloads 0
Ending the Ebola Virus Scourge A Case for Natural Products
We investigated the binding affinities of antiviral of ethno medicinal origin to five Ebola viral proteins by in silico molecular docking simulations. One hundred and seventy three compounds were obtained from literature...
Sustained Release Multiple Unit Dosage Form for the Oral Day Delivery of Dexketoprofen Trometamol
The aim of this study was to prepare sustained release multiple unit dosage form (MUDF) for the oral day delivery of the frequently administered and the highly water soluble drug, dexketoprofen trometamol (DT). The drug...
Advances in Anticancer & Marine Drug Research An Overview
Out of earth’s total surface area, more than 70% is covered with marine/salty water. World oldest, most revered & holy texts, the Vedas, term the Ocean as ‘Ratnakar’, or the bestower of immense riches. From times immemor...
Chikungunya Emerging Health Crises in Pakistan: Are we Going in the Right Direction
The unstable health care system of Pakistan saw a major setback in the form of dengue outbreak in 2011. Despite massive governmental efforts, with each passing year dengue continues to cause significant morbidity and mo...
Preparation Modification and Characterization of a Hydrogel Based on Polyacrylic and Polymetacrylic Acid as a Potential Carrier for Drug Delivery Systems
Complexes of polyacrylic acid (PAA) and polymethacrylic acid (PMA) in presence of sodium alginate (SAL) during redox polymerization of polyacids were formed. They were characterized by IR spectroscopy and viscometry. The...