Drug-Related Problems in Hypertensive Patients with Multiple Comorbidities
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 3
Abstract
Hypertensive patients with multiple comorbidities often received multiple medications to achieve target blood pressure and to treat other comorbidities which can lead to the occurrence of drug-related problems (DRP). The objectives of this study were to identify the DRPs and the most common drugs associated with DRPs in this population. The study was conducted prospectively involving hypertensive patients with multiple comorbidities at a tertiary care centre. Data were obtained from bed head tickets and from the interview with eligible patients. The assessment of DRPs was based on Pharmaceutical Care Network Europe Foundation (PCNE) Classification of DRP tools version 5.01. From the total of 80 patients, 88.8% of the patients had at least one DRP. A total number of 172 DRPs were identified with an average of 2.15 ± 1.5 DRPs per patient. The most frequent category of DRP was interactions (33.7%), followed by adverse reactions (23.9%), drug choice problems (14.5%), dosing problems (13.4%), others (8.1%) and drug use problems (6.4%). Antihypertensive agents were the most common drugs associated with DRPs in this population. Significant associations were found between elderly and the occurrence of adverse reactions, and between renal impairment with the occurrence of drug choice problems and over dosage problems. This study demonstrates that DRPs were frequently observed in hypertensive patients with multiple comorbidities. Thus interventions to resolve these problems are important to ensure the effectiveness and safety of the prescribed medications.
Authors and Affiliations
Redzuan AM*, Ramli AR and Pheng MTH
Keywords
Related Articles
- EP ID EP745761
- DOI 10.23880/oajpr-16000113
- Views 29
- Downloads 0
Facile Synthesis of Copper Sulphide Nanoparticles using Trichoderma Herzlianism and Antibacterial Efficiency Enhancement by Gentamicin Sulfate
The application of biosynthesized semiconductor nanomaterials has gained recent attention towards pathogenic bacteria. This study reports cost- effective, eco- friendly biosynthesis of copper sulphide nanoparticles (CuS...
Consumption of Wild Tulsi Leaves May Protect Against Methicillin-Resistant Staphylococcus Aurous (MRSA) Infection!
Nosocomial infections are caused by the evolution of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Staphylococcus aureus (VRSA). It is concerning because the prevalence of fluoroquinolone an...
The Evolving Definition of Comparative Effectiveness Research: Lessons for Researchers Planning and Designing a Clinical Development Program
Among the many challenges that must be overcome in successfully developing a novel drug treatment is to understand and prepare evidence that will ultimately be required by regulators and reimbursement authorities. Payers...
Transferosomes for Trans-Nasal Brain Delivery of Clonazepam Preparation Optimization Ex Vivo Cytotoxicity and Pharmacodynamic Study
Clonazepam (CZ) is a benzodiazepine derivative that is used mainly in the treatment of status epilepticus (SE). Intranasal (IN) administration of nano-carrier systems generally have the ability to deliver the drug to the...
Determination of Hydrochlorothiazide in Plasma by High Performance Liquid Chromatography (HPLC)
Retention times for hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ, internal standard) are highly temperature- (20°-26°) as well as pH-dependent (3.5-6.3). Separation of both drugs is maximized in the pH range 6.3 to...