Drug Susceptibility of Uropathogens: Need for New Antimicrobial Guidelines
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 7
Abstract
Background: There is increased prevalence of drug resistant strains responsible for community acquired urinary tract infection. To know the drug susceptibility of uropathogens to routinely used antibiotics. Material and Method: The midstream urine specimen was collected from clinically suspected cases of urinary tract infection they were subjected for standard processing protocol to isolate the pathogen and study their susceptibility. Results: Of the 1057 urine samples were studied over a period of one year out of which 234 samples (22%) yielded significant growth of single organism In the present study E.coli(55%),Klebsiella species (16%), Enterococcus fecalis, 09% Staphylococcus aureus, 04% , Nonfermenters excluding Pseudomonas spp (3%),Citrobacter spp(3%),Streptococcus spp(2%),Pseudomonas spp(2%),Proteus spp(2%)Enterobacter spp(2%),coagulase negative Staplococcus spp(01%) and Providentia spp(0.5%) Antibiotic sensitivity and resistance analysis was performed by the disc diffusion method employing multiple antibiotic discs. E.coli showed variable antimicrobial resistance to different antibiotics as 85%,70%, 40%,and 28% of the isolates were found to be resistant to ampicillin ciprofloxacin , gentamicin, amikacin respectively. Klebsiella species showed resistance to various betalactam antibiotics 62%-100% ciprofloxacin 71%, gentamycin 67% and Nitrofurantoin 57%cefatoxime 80% Staphylococcus isolates showed high resistance rate against ampicillin82% , norfloxacin 82%,ciprofloxacin70% ,ceftriaxazone 73%, cefatoxime 67% and cotrimaxazole 65% all were sensitive to vancomycin and linozolid Non fermenters (excluding pseudomonas species) showed high degree of resistance to almost all the antibiotics used routinely. Pseudomonas isolates were found to be resistant to gentamycin 80%) cotrimaxozole100%,norfloxacin100% ,and amikacin100% Enterobacter spp were 100% sensitive to Nitrofurantoin and these isolates were almost resistant to other group of antibiotics. Antibiotic susceptibility data revealed that majority of the isolates were resistant against 3 or more antibiotics that is 95% of the bacterial pathogens are multidrug resistant and the percentage of ESBL producers detected among E.Coli and Klebsiella species were 26%&40% respectively
Authors and Affiliations
Dr. BV Shamsundar
Keywords
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