DRUG TOLERANCE/INTOLERANCE IN DOMESTIC DOG (Canis lupus familiaris) WITH MDR1 GENE DEFECT
Journal Title: Folia Pomeranae Universitatis Technologiae Stetinensis Agricultura Alimentaria Piscaria et Zootechnica - Year 2017, Vol 41, Issue 332
Abstract
Ivermectin is a drug used to fight endo- and exoparasites in animals at regular base in veterinary practice. Basically this substance is safe for mammals. The mechanism of its action is based on dysfunction of nerve impulses conduction. P-glycoprotein is a membrane transport protein present in endothelial cells of lungs, kidneys, liver and pancreas. It prevents toxin penetration into the brain neurons and many other organs outside central nervous system including barriers: blood–testis, blood–placenta, blood–urine. This protein is coded by Multi Drug Resistance gene 1 (MDR1 gene) and is located in membranes of blood-brain barrier cells. When a mutation in MDR1 gene appears the protein isn’t able to function properly. In that case ivermectin goes to canine central nervous system cells and induces neurotoxic clinical signs, that is why early diagnostic is very important especially to prevent poisoning. The reasons and effects of the mutation as well as elements of molecular diagnostic that allows to identify the mutation were describe in this manuscript. Moreover, medicines that can induce neurotoxic signs in dogs with mutation in MDR1 gene were listed.
Authors and Affiliations
Sebastian ZDAŃKOWSKI, Joanna GRUSZCZYŃSKA, Katarzyna FISZDON, Beata GRZEGRZÓŁKA, Wiesław ŚWIDEREK
Keywords
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