Abstract

Introduction: Epilepsy is a common medical condition characterized by repeated seizures due to a disorder of the brain cells. the data was limited regarding the prescribing pattern and side effects of various anti epileptic drugs in various population. The aim of present study was to evaluate the effective use of anti epileptic drugs in the management of various types of epileptic seizures over a period of six months. Materials and methods: A prospective observational study was conducted among epileptic patients on follow up at neurology department of Guntur city hospital. During the six months study period, epileptic patients who were prescribed with AED’s (Anti Epileptic Drugs) were in this study. Data were collected through the hospital medical records. Results: A total 150 patients included in this study, in this n:89 (57.33%) were males, 61 (40.66%) females. The most common type of seizures diagnosed as generalised Tonic Clonic seizures 108 (72.0%) effected with GTC’s, males 62 (57.40%), females 46 (42.59%) partial seizures 22 (14.66%). Mono therapy commonly used in the treatment of epilepsy 97 (64.66%), dual therapy 41 (27.33%) poly therapy 12 (8.0%). Among which new anti epileptic drugs levetiracetam was the most commonly utilised single drug and multiple anti epileptic drug followed by Valproic acid, Carbamazepine, and Phenytoin. In this study 52 adverse drug reactions are identified. Conclusion: This study highlights the need of drug utilization evaluation and therapeutic drug monitoring of epileptic patients. Improving the rational use of anti epileptic drugs like Levetiracetam, Lamotrigine, Topiramate etc. Most of the ADR’s are mild and predominant in females.

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