Formulation and Evaluation of Orodispersible Tablets of Ambroxol Hydrochloride
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 6
Abstract
The present study is to design and develop a stable solid oral dosage form of dispersible tablets to deliver with optimum concentration of drug at desired site at specific time comparable to the innovator product with better stability, high production feasibility, and excellent patient compatibility. Formulations were made by wet granulation technique. All the formulations were subjected to physicochemical analysis and out of them Formulation 9 was found to be satisfactory when compared to other formulations. The disintegration time 29.25 sec and percentage of drug release (94.73 %) were found to be satisfactory and it matches with the innovator. So, the batch size was increased in further trial to check the reproducibility (Formulation 9).Finally loaded for stability as per the ICH guidelines.
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