Abstract

Objective: The objective of the study was to formulate & evaluate Solid Dispersions of a poorly water soluble drug like Indomethacin, as model drug by using hydrophilic polymers like Polyethylene glycol-4000 and Polyvinyl Pyrrolidine K30. Experimental approach: Melting fusion Method was employed for the preparation of Solid Dispersion of Indomethacin. The various batches of prepared Solid Dispersion using PEG-4000 and PVP K30 were subjected for drug content analysis. The prepared Solid Dispersions were characterized by Fourier transformed infrared spectroscopic analysis (FT-IR), to ascertain for any interaction between the drug and the polymers used and to confirm the encapsulation of the drug with in polymer matrix Findings & Discussions: All Solid Dispersion Formulations satisfies the dissolution acceptance level (Qmin=75%), where B3 shows better resistance to drug degradation in dissolution medium pH 7.4 phosphate buffer. Percentage cumulative drug release was 87.11 % within 40 minute in the PEG (1:5) batch (for pure drug only 77 %), which was maximum release rate achieved among all batches, so exposure time of Indomethacin to the dissolution medium is very less. Tablet shows good release, up to 86.98 % of the drug was release to the dissolution media within 40 minute. For the immediate release tablet dissolution acceptance level (Qmin=75%) which was satisfied. Conclusion: The tablets of that batch PEG (1:5) had considerable content uniformity with good drug release pattern. Thus From the discussion it was concluded that PEG increases the solubility of Indomethacin as compared to PVP K30 at 1:5 drugs to polymer ratio.

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