Abstract

Aim of study: To evaluate hepatoprotective effect of Unani formulation (Qurs Rewand). Materials and Methods: The study was conducted on adult Wistar albino rats of either sex weighing 150-200 g. Animals were divided into five groups of 6 animals each – I (Plain control), II (Negative control–CCl4 treated group), III (Sylimarin treated group), IV and V (UPF treated groups). Hepatotoxicity was induced by single administration of CCl4 (2ml/ kg I.P., 1:1 in liquid paraffin) in group II, III, IV & V on 7th day of treatment. The UPF was administered in a dose of 50 mg/kg and 100 mg/kg, once daily, orally for 7 days in group IV and V respectively. Silymarin was administered orally in the dose of 100 mg/kg body weight, once daily for 7 days in III group and served as standard control. On the 8th day all the animals were sacrificed and the blood was collected. Serum was separated for biochemical estimations. The serum was estimated for ALT, AST, bilirubin, alkaline phosphatase, total protein and TBARS. Histological study of liver was done.Results: The mean serum ALT, AST, bilirubin, alkaline phosphatase, and TBARS were decreased significantly as compared to CCl4 treated group.While total protein was increased significantly as compound with CCl4 treated group. The histological study showed signs of recovery and regeneration in damaged liver cells as compared to CCl4 treated group. Conclusion: The study demonstrated significant hepatoprotective activity of Qurs Rewand (Unani Polyherbal formulation).

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