Abstract

Objective: The aim of present work is mask the bitter taste of Naproxen sodium and formulate orodispersible tablets of Naproxen sodium. Experimental work: The bitter taste of drug was masked by using Ion exchange resin orodispersible tablet of Naproxen sodium was prepared by using super disintegrant. All the prepared tablets were evaluated for their pre compression as well as post compression properties. Results and Discussion: Optimization of Naproxen sodium orodispersible tablet by 32 full factorial designs. The independent and dependent factors were concentration of cross providone, concentration of sodium starch glycolate and disintegration time, Drug release (%) respectively. No interaction was found between drug and excipient as confirmed by DSC studies. Optimized formulation shows better post compression property and In-vitro drug release. Conclusions: Orodispersible tablet gives onset of action and quick relief to patient compliance. Oral delivery appears better and effective drug deliverysystem as compared to other drug delivery system. Many ingredients used in the formulation are highly stable and safe for the oral delivery and that pharmaceutical ingredient into ODT is used in treatment of various diseases like joints pain, headaches backaches and Rheumatoid arthritis.

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