Abstract

Objective:The hitherto unknown effects of peel extract of Beta vulgaris root in regulating hyperthyroidism was investigated in male albino mice. Method: Hyperthyroidism was induced by L-thyroxine(L-T4 ) at a pre-standardized dose of 0.5 mg/kg for 12 consecutive days and then the effects of alcoholic extract of the test peel, at two different doses (250 and 500 mg/kg/d for 15 days)were investigated in the hyperthyroid mice considering tissue lipid peroxidation (LPO), super oxide dismutase (SOD), catalase (CAT), glutathione(GSH) and the concentrations of thyroid hormones, glucose and lipids as main parameters. Result:L-T4 administration enhanced the levels of serum triiodothyronine (T3) and T4 both as well as the hepatic LPO(p<0.001) with a parallel decrease in the levels of antioxidants(SOD and CAT) and serum lipids. While, after the treatment of both the doses of beet root extract in hyperthyroid animals, LPO was decreased; the values of SOD, CAT and GSH were enhanced significantly in liver tissues with a concomitant decrease in serum thyroid hormone levels, suggesting the antithyroid role of beet root. Conclusion:The alcoholic extract of B.vulgarisroot possesses potential antioxidative and thyrotoxicosis ameliorating activities.

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