Formulation and In-vitro evaluation of immediate release Olanzapine tablets
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 2
Abstract
The main objective of the present study was to formulate stable immediate release Olanzapine tablets matching in invitro dissolution with the marketed formulation. Olanzapine is hygroscopic and sensitive to heat and moisture. The present work had two objectives-To develop stable Olanzapine tablets and matching in dissolution with the marketed formulation. Tablets were manufactured by direct compression process. Superdisintegrants were chosen to reduce the disintegration time and match the dissolution profile that of marketed formulation. It was found that the dissolution profile of trial T7 which was formulated with 2% Crospovione intragranular and 2% Crospovidone extragranular was similar to marketed formulation. The 10mg and 15mg strengths were formulated by common blend approach, with formula similar to optimized formula of 20mg tablets. The dissolution profiles of 10 mg and 15mg strengths were compared with 20mg strength and the results were found to be satisfactory.
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