Abstract

The present investigation was carried out to study the antidiabetic activity of methanolic extract of entire plant of Waltheria indica L. and its effect on the lipid profile, antioxidant properties and histopathology of liver and kidney tissues of alloxan induced diabetic models. Studies were carried out in normal and alloxan induced diabetic rats treated with doses 200mg/kg and 400mg/kg of Waltheria indica L. extract where, Carboxy Methyl Cellulose (CMC) was acted as vehicle medium and Glibenclamide was used as standard drug. Decreased blood glucose level of the test animals showed that the extract has significant antidiabetic activity over the diabetic control group. The results also indicated dose dependent effect. The antidiabetic properties of the extract may be due to increased uptake of glucose at the tissue level. The extract also produced a significant increase in High Density Lipoprotein (HDL), Super Oxide Dismutase (SOD), Catalase (CAT), Reduced Glutathione (GSH) and Glutathione Peroxidase (GPx); significant decrease in Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein (LDL), Very Low Density Lipoprotein (VLDL), Lipid Peroxidation (LPO), in test groups. This clearly represents the effect of test drugs in the antioxidant property and lipid profile of the test animals. The results obtained from the experiment provided the scientific support to the enthnomedicinal use of Waltheria indica L. for the treatment of diabetes mellitus.

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