dsRNA Virus Model Molecule and the Mechanism of PRRs and its Research Progress in Female Reproductive Tract Infections
Journal Title: International Journal of Biomedical and Clinical Analysis - Year 2021, Vol 1, Issue 1
Abstract
Female animal genital tract opening on the body surface, prone to bacterial, viral, parasitic, and other pathogenic microorganism infections, leading to genital tract infectious diseases, such as endometritis, cervicitis, vaginitis, etc. Severe infection can lead to infertility, abortion, and even fetal death. Double-stranded RNA (dsRNA) is an important model molecule, which is widely present in the genome of viruses and generated in the process of virus replication. In mammals, dsRNA is considered to be an innate immune response signal for viral infection, which binds to the corresponding pattern-recognition receptors (PRRs) In vivo and then exerts biological functions. This review summarizes the signal transduction pathway induced by the binding of dsRNA model molecules to PRRs, research status of female genital tract infections and research progress of dsRNA in simulating viral infection in the female genital tract.
Authors and Affiliations
Yuting Pan, Yan Zhang, Xiaoxu Li, Juping Li, Ling Xu, Wencan Wang, Min Cui, Mingwu Tian
Keywords
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- EP ID EP724369
- DOI https://doi.org/10.61797/ijbca.v1i1.48
- Views 58
- Downloads 0
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