DUAL ANTICANCER DRUG LOADED METHOXY POLY (ETHYLENE GLYCOL)-POLY (ε-CAPROLACTONE) BLOCK COPOLYMERIC MICELLES AS NOVEL DRUG CARRIERS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: Curcumine (CUR) and rapamycin (RAPA) are two potent hydrophobic anticancer drugs. The clinical and preclinical applications of anticancer formulations are limited due to use of toxic excipients and poor bioavailability. In the present study, an approach has been made to develop CUR and RAPA loaded MePEG/PCL di-block copolymeric micelles keeping in the view to make excipient free formulation with slow release of drugs.Methods: The CUR and RAPA loaded MePEG/PCL di-block copolymeric micelles were prepared. Physico-chemical characters like size, surface charge and encapsulation efficiency were measured. The in vitro release studies was carried out in pH 7.4 to evaluate the sustained release properties of micelles.Results: MePEG/PCL di-block copolymeric micelles were efficiently encapsulate both the drugs, i. e. CUR (~ 64 %) and RAPA (~ 94 %) in the core and have loading capacity of ~ 12 % (CUR) and ~ 29 % (RAPA). The zetasizer measurement shows that particles have size range 128 nm to 176 nm with a negative zeta potential. SEM and AFM studies reveled that micelles have smooth exterior surface. The XRD and DSC studies explain that the drugs are uniformly distributed in the polymer matrix. The dual drug loaded micelles have sustained in vitro drug release activity as estimated in phosphate buffer (pH 7.4).Conclusion: These MePEG/PCL di-block copolymeric micelles are capable of carrying both the hydrophobic anticancer drugs and the encouraging results suggest further studies to evaluate the bioavailability parameters as well as suitability of the formulation.
Authors and Affiliations
Anjan Kumar Mohanty, Guru Prasad Mohanta
Keywords
Related Articles
- EP ID EP579591
- DOI -
- Views 84
- Downloads 0
UTILIZATION OF UNSERVICEABLE STRAWBERRIES FOR PRODUCTION OF ELLAGIC ACID AND ITS ENHANCEMENT BY ASPERGILLUS NIGER
Objective: Use of Aspergillus Niger (616) for the fabrication of ellagic acid from unserviceable strawberry as a substrate which is readily and chiefly available from Agro-industries and farm waste.Methods: The ellagic a...
ANTIEPILEPTIC ACTIVITY OF SOME NOVEL SUBSTITUTED FLUORO BENZOTHIAZOLE DERIVATIVES
Objective: The aim of the study is to investigate and to reveal the antiepileptic activity of fluoro substituted benzothiazole derivatives (FBTDs) in experimental induced epilepsy in mice.Methods: The acute oral toxicity...
DESIGN, FABRICATION AND EVALUATION OF SS 316 PUNCH DIE SET FOR ACCURATE SIZING OF SODIUM CROMOGLYCATE OCULAR INSERTS
Objective: Objective of the study was to design, fabricate & evaluate punch die set for accurate sizing of sodium cromoglycate ocular inserts prepared using few polymers and to compare with physico-chemical results o...
SYNTHESIS OF SOME NOVEL 3,5,6-TRISUBSTITUTED-[1,2,4]TRIAZOLO[3,4-c][1,2,4] TRIAZINESAS DNA PHOTOCLEAVING AGENTS
Objective: To develop an easy and non toxic method for synthesis of some novel triazolotriazines via oxidative transformation of triazinylhydrazones using iodobenzene diacetate and to evaluate their DNA photocleavage pot...
FORMULATION AND EVALUATION OF GLIPIZIDE MICROEMULSION
Objective: The aim of the present study was to formulate a microemulsion for the oral delivery of Glipizide.Methods: Microemulsion systems composed of oleic acid, isopropyl myristate as oils; tween 80, span 20 and cremop...