DUAL INHIBITION OF THE TWO SOURCES OF CHOLESTEROL. THE MODERN METHODOLOGY OF REDUCING CARDIOVASCULAR RISC
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 2
Abstract
This study evaluated the efficacy and safety of Ezetimibe co-administered with Simvastatine therapy in 104 hypercholesterolemic patients with coronary heart disease (CHD) or diabetes who had not achieved their low-density lipoprotein cholesterol (LDL-C) goal <100mg/dl while on a stable dose of Simvastatine 20mg/day. Significantly more patients achieved an LDL-C goal <100mg/dl with Ezetimibe than Placebo (51% vs. 35%). Compared to Placebo, co-administration of Ezetimibe with Simvastatine led to significantly greater reductions in LDL-C, total cholesterol, triglycerides, non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein B; HDL-C was as well increased. Co-administration of Ezetimibe and Simvastatine was well tolerated, with an overall safety profile similar to Simvastatine alone.
Authors and Affiliations
Gabriela Dale, M. I. Popescu, Loredana Popa, A. R. Popa, R. Fritsch
Keywords
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