Dual trigger with gonadotropin-releasing hormone and human chorionic gonadotropin for poor responders
Journal Title: UNKNOWN - Year 2018, Vol 19, Issue 2
Abstract
Objective: To compare metaphase II (MII) rate, fertilization rate, and embryo quality with dual trigger gonadotropin-releasing hormone agonist (GnRH) and normal dose human chorionic gonadotropin (hCG) versus a normal dose hCG trigger in antagonist intracytoplasmic sperm injection (ICSI) cycles of poor ovarian responders. Material and Methods: Patients defined as poor ovarian responders according to the Bologna criteria who underwent ICSI with GnRH antagonist protocol and triggered with dual trigger or hCG alone for oocyte maturation. Main outcome measures were MII rate, fertilization rate, and embryo quality. Results: Total gonadotropin doses and E2 levels on trigger day were higher in the hCG trigger group. There were no significant differences with regard to implantation rate (p=0.304), biochemical pregnancy rate (p=0.815), clinical pregnancy rate (p=0.378), and ongoing pregnancy rate (p=0.635) between the groups. Conclusion: Dual trigger of oocyte maturation with GnRH agonist and normal dose hCG in poor responders does not demonstrate improved oocyte maturation, clinical pregnancy, and ongoing pregnancy rates.
Authors and Affiliations
Ahmet Eser, Belgin Devranoğlu, Evrim Bostancı Ergen, Ciğdem Yayla Abide
Keywords
Related Articles
- EP ID EP365023
- DOI 10.4274/jtgga.2017.0045
- Views 72
- Downloads 0
Platelet-to-lymphocyte ratio: A new inflammatory marker for the diagnosis of preterm premature rupture of membranes
Objective: Preterm premature rupture of membranes (PPROM) is closely related with maternal and fetal complications. Therefore, early diagnosis is extremely important to provide maternal and fetal well-being. Many inflamm...
The opinions and thoughts of women who underwent hysterosalpingography for the first time: Letter to the editor
.
Management of fibroids prior to in vitro fertilization/ intracytoplasmic sperm injection: A pragmatic approach
Fibroids are relatively common in women undergoing in vitro fertilization (IVF) treatment due to their high prevalence in women. It is generally accepted that submucosal fibroids are deleterious to IVF outcomes and their...
JTGGA CME/CPD CREDITING
.
Detection of major anomalies during the first and early second trimester: Single-center results of six years
Objective: Fetal structural malformations affect approximately 2-3% of all pregnancies. Only focusing on trisomy screening in first trimester and deferring the anatomic screening to second trimester may result with late...