Duloxetine Modulates Vincristine-Induced Painful Neuropathy in Rats
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 9
Abstract
Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. Vincristine-induced peripheral neuropathy models showed mixed sensory motor neuropathy. Duloxetine is the first Food and Drug Administration–approved prescription drug for the management of diabetic peripheral neuropathic pain. The present study aimed to explore the dose-dependent effect of duloxetine on vincristine-induced neuropathy in rats. Rats were injected with vincristine (0.1 mg/kg/day) to induce peripheral neuropathy. Treatment with duloxetine (10, 20, 30 mg/kg/day) for six weeks improved behavioural parameters, nociceptive response and nerve conduction velocity. Moreover, histopathology of the sciatic nerve revealed marked improvement in the pathological changes after duloxetine treatment. Also, the high doses of duloxetine (20 or 30 mg/kg) significantly decreased the expression of microglia marker (CD11b). We concluded that duloxetine in high doses can significantly attenuate the painful neuropathy induced by vincristine. Spinal microglia involvement may be considered as an assisting mechanism.
Authors and Affiliations
S. M. Greish , N. M. Abogresha , S. A. Zaitone
Keywords
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