Duration of treatment of problematic infantile hemangioma with oral propranolol: a single institutional review
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Aims: To study the use of propranolol as a single therapy in problematic infantile hemangioma with special reference to the total duration of treatment and its short term outcome(s). Methods: Single institutional retrospective study of patients of problematic infantile hemangioma treated with propranolol between January 2016 to December 2017. Assessment was done by change in colour , redness & size. Accordingly, outcome was graded as excellent, good/partial and no response. Results: 17 girls and 9 boys with problematic infantile hemangioma were initiated treatment with propranolol at the mean age of 7 months(range 2-24 months) for a mean duration of 12 months(range 6-18 months). Head and neck was the most common site(65%). Complete/excellent response was seen in 16 patients(61.6%), good/partial response in 8(30.7%) and no response in 2 patients(7.7%). Rebound was seen in 3 patients(12%). Conclusions: Use of oral propranolol in problematic infantile hemangioma is safe, feasible and effective with very few adverse effects at the recommended dosage of 2-3 mg/kg/day in divided dosage. Treatment should continue till the complete regression of the lesion for at least 12 months substantiated by the fact that all the 3 cases of rebound had received treatment for lesser duration and showed excellent response to longer duration of treatment.
Authors and Affiliations
Sujay Kumar Maitra, Sukanta Kumar Das, Rajarshi Kumar
Keywords
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