Study on Diastolic Dysfunction in Rheumatoid Arthritis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Aim: The aim of this study was to evaluate left ventricular diastolic dysfunction in patients with rheumatoid arthritis with special regard to disease activity and duration. Methods: 110 patients of seropositive Rheumatoid arthritis during the study period from January 2018 to July 2018 were included in the study. All patients were assessed using DAS 28 score for disease activity and transthoracic echocardiography using Mmode, 2D, conventional doppler echocardiography and TDI. Results: Using DAS 28 score patients were categorized into those with inactive disease (score <2.1) and those with active RA (score>2.1). Among conventional Doppler early diastolic flow velocity (E), late diastolic flow velocity(A) were measured. E/A was found to be lower in RA patients. From TDI parameters, e’ (early diastolic), a’(late diastolic) annular velocities were measured and E/e’ and e’/a’ ratios were calculated. We found that e’ was found to be lower in patients with RA and E/e’ ratio was found to higher in RA patients consistent with diastolic dysfunction. There was a strong correlation between CRP positivity and diastolic dysfunction (p<0.05); disease activity also positively correlated with diastolic dysfunction. Conclusion: It is concluded that Rheumatoid arthritis patients in the absence of clinical evidence of heart disease show diastolic dysfunction. CRP and disease activity have a strong correlation with diastolic dysfunction. However we could not demonstrate any relation between the duration of disease and diastolic dysfunction.
Authors and Affiliations
Ramesh Subramanian, Balamurugan Shanmugam, Arumugam Moongilpatti Angappamudali
Keywords
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