DYNAMICS OF CHANGES IN THE CELLULAR COMPOSITION OF VARIOUS STRUCTURAL AND FUNCTIONAL ZONES OF PEYER'S PATCHES OF OFFSPRING BORN FROM FEMALE RATS WITH HYPOTHYROIDISM
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 10
Abstract
Clinical observations indicate that hypothyroidism negatively affects the structural and functional state of the body as a whole, including the immune system. In the body of patients with hypothyroidism, various immune disorders develop, which depend on the level of thyroid hormones and the duration of the disease. To date, the structural features of the immune system organs, including Peyer's patches, of offspring born from mothers with thyroid hormone deficiency have not been sufficiently studied. The aim of the study was to elucidate the effect of experimental maternal hypothyroidism on the cellular composition of various structural and functional zones of Peyer's patches in early postnatal ontogenesis. Hypothyroidism was induced in white outbred female rats weighing 180-200 g by administering mercazolil per os at a dose of 5 mg/kg for 21 days. The PB of the offspring born from them was studied using morphological, morphometric and statistical research methods. It has been established that under experimental hypothyroidism in animals there is a decrease in the mass of lymphoid organs and their cellular composition. Quantitative shifts in various PB zones progressed on the 21st day of experimental hypothyroidism and manifested themselves as a decrease in the number of cells in all structural and functional zones, mainly due to lymphocytes, macrophages, plasmacytes and destructive cells in all PB zones. In all zones, the total number of cells showed a pronounced tendency to decrease.
Authors and Affiliations
Ishandjanova S. Kh. , Otazhanova A. N. , Rahmatullayeva R. V. , Fozliyeva M. V.
Keywords
Related Articles
- EP ID EP724030
- DOI 10.5281/zenodo.10030218
- Views 41
- Downloads 0
CLINICAL AND ORGANIZATIONAL ASPECTS OF CARDIAC ARRHYTYMIAS AT THE HOSPITAL STAGE OF MEDICAL CARE
This article highlights the clinical and organizational aspects of heart rhythm disturbances at the hospital stage of medical care, as well as the features of rhythm and conduction disturbances in patients with chronic p...
LEXICO-SEMANTIC AND THEMATIC CHARACTERISTICS OF ADVERTISING IN UZBEKISTAN
This article analyzes the research of advertising texts, their lexical-semantic and thematic features. As a result of the study of the language features of advertising texts, we found that advertising is a kind of comple...
SCREENING BACTERIAL STRAINS OF BACILLUS GENERATION BY PROTEASE ACTIVITY
Today, medicines account for more than 15% of the total volume of all microbial biotechnology products produced in the world. Enzymes occupy a special place among medicinal substances. For example, proteolytic enzymes ar...
EVOLUTION OF THE METHOD OF RESTAURATION OF MANUSCRIPT SOURCES
This article briefly covers several methods used in the restoration of ancient manuscripts, their importance, scope of application, reasons for deprecation and introduction of other new methods into the restoration proce...
A METHODOLOGICAL MODEL OF DEVELOPING CREATIVE COMPETENCE OF STUDENTS IN ART POTTERY COURSES
The article is aimed at the formation of students' creative competence necessary to create an image in pottery, i.e. imaginative thinking, creative imagination, artistic observation, visual memory, emotional attitude to...